Document Detail


Endogenous nickel release as a possible cause of coronary vasoconstriction and myocardial injury in acute burn of rats.
MedLine Citation:
PMID:  6616767     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the present study was to test the hypothesis that endogenous nickel release may play a role in myocardial depression in the acute phase of burn shock in rats. Serum nickel concentration (Se-Ni) measured by atomic absorption spectrophotometry, the sensitivity of isolated perfused hearts to exogenous nickel chloride (0.01 mumol/l), and ultrastructural myocardial alterations, as well as subcellular localization of endogenous Ni by the dimethylglyoxim method, were analyzed in the first week after standardized third-degree full thickness skin thermal burn covering 20-25% of the body surface. In the first 2 days after burn a significant fivefold increase of Se-Ni concentration was observed which leveled off by the end of the first postburn week. The coronary vascular resistance increasing effect of exogenous NiCl2 grew significantly in the first 3 h after burn, decreased to control in the 2nd postburn day, and increased again in the second half of the week after burn. Both ultrastructural damages and nickel containing reaction products could be observed in the myocardium 7 days after burn. The experimental results suggest that endogenous nickel release may play a role in coronary vasospasm and consequent myocardial depression in the acute phase of burn shock in the rat.
Authors:
G Rubányi; K Szabó; I Balogh; M Bakos; A Gergely; A G Kovách
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Circulatory shock     Volume:  10     ISSN:  0092-6213     ISO Abbreviation:  Circ. Shock     Publication Date:  1983  
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0414112     Medline TA:  Circ Shock     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  361-70     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Animals
Burns / complications*
Cardiomyopathies / etiology
Coronary Vasospasm / etiology*
Female
Heart / physiopathology*
Male
Myocardium / ultrastructure
Nickel / adverse effects*,  blood,  metabolism*
Rats
Shock, Traumatic / complications*
Chemical
Reg. No./Substance:
7440-02-0/Nickel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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