Document Detail

Endogenous neuropeptides in patients with acute traumatic head injury, I: cerebrospinal fluid beta-endorphin levels are increased within 24 hours following the trauma.
MedLine Citation:
PMID:  8868299     Owner:  NLM     Status:  MEDLINE    
The changes in the cerebrospinal fluid (CSF) beta-endorphin (beta-end) levels within 24 h following the trauma were examined in 45 patients with head injuries. CSF samples obtained from 25 healthy subjects who had minor surgical operations under spinal anaesthesia were included as the controls. Patients with head injuries were evaluated according to their Glasgow Coma Scale (GCS) scores on admission to the neurosurgery clinic and four subgroups were formed as follows: Group I: minor head trauma (GCS: 13-15) without skull fracture; Group II: mild head injury (GCS: 13-15) with skull fracture; Group III: moderate head injury (GCS: 8-12) and Group IV: severe head injury (GCS: < 8). All patients with head injury had significantly higher CSF beta-end levels than the controls (P < 0.001). The levels in patients with mild head injury (Group II) were significantly higher than those with severe head trauma (Group IV) (P < 0.001). There was not any correlation between the CSF beta-end changes and the GCS scores of the patients. Endogenous opioid peptides are suggested to have a role in central nervous system (CNS) injuries. However, the CSF levels of beta-end in patients with varying degrees of head trauma have not yet been clearly documented in the literature. In the present study, significant changes in CSF beta-end levels are detected in patients with a wide range of head trauma (from minor head trauma to severe injury); however, the increased CSF beta-end levels were not correlated to the early prognosis of the patients.
H Paşaoglu; E Inci Karaküçük; A Kurtşoy; A Paşaoğlu
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuropeptides     Volume:  30     ISSN:  0143-4179     ISO Abbreviation:  Neuropeptides     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1997-03-05     Completed Date:  1997-03-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8103156     Medline TA:  Neuropeptides     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  47-51     Citation Subset:  IM    
Department of Clinical Biochemistry, Erciyes University, Kayseri, Turkey.
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MeSH Terms
Acute Disease
Child, Preschool
Craniocerebral Trauma / cerebrospinal fluid*
Middle Aged
Neuropeptides / cerebrospinal fluid*
beta-Endorphin / cerebrospinal fluid*
Reg. No./Substance:
0/Neuropeptides; 60617-12-1/beta-Endorphin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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