| Endogenous neurogenesis after intracerebral hemorrhage. | |
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MedLine Citation:
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PMID: 22237708 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Currently, it is accepted that brain injury promotes endogenous neurogenesis in mammals, primarily in the subventricular zone (SVZ), and newborn cells can migrate to the injured area. We examined the pattern of endogenous neurogenesis in adult rats after intracerebral hemorrhage (ICH) that was caused by intrastrial administration of collagenase type IV. Our results showed that ICH induced strong endogenous neurogenesis between 72 hours and 7 days after injury, but that the majority of newborn cells did not survive longer than 3 weeks due to apoptosis-mediated cell death. Furthermore, endogenous neurogenesis remained into a small extent at least 1 year after ICH. Because of the growing interest in new strategies for brain regeneration, these data suggest endogenous neurogenesis and inhibiting apoptosis of newborn neuroblasts as potential strategies to improve the consequences of hemorrhagic stroke in humans. |
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Authors:
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L Otero; M Zurita; C Bonilla; M A Rico; C Aguayo; A Rodriguez; J Vaquero |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Histology and histopathology Volume: 27 ISSN: 1699-5848 ISO Abbreviation: Histol. Histopathol. Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-01-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8609357 Medline TA: Histol Histopathol Country: Spain |
Other Details:
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Languages: eng Pagination: 303-15 Citation Subset: IM |
Affiliation:
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Neuroscience Research Unit, Puerta de Hierro-Majadahonda Hospital, Madrid, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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