Document Detail

Endogenous methemoglobinemia associated with diarrheal disease in infancy.
MedLine Citation:
PMID:  8811515     Owner:  NLM     Status:  MEDLINE    
Infantile diarrhea is sometimes associated with methemoglobinemia. To determine the significance of intestinal bacterial infection or overgrowth and other predisposing factors in this entity, we evaluated prospectively 45 consecutive patients who were admitted for gastroenteritis and methemoglobinemia between March 1980 and September 1992. All the patients were younger than 3 months of age. In 95% of them, methemoglobinemia occurred between the ages of 15 days to 2 months. The peak mean methemoglobin concentration was 9.4% (range, 2.4-57%). Although stool cultures were positive in only 22% of the infants, the epidemiologic data strongly suggested a bacterial or viral etiology in our study population: for 12 years, there was a significant decrease in the annual incidence of methemoglobinemia associated with diarrhea in parallel to the decrease in infantile diarrhea due to known pathogens throughout the country in the same period. There was also a marked seasonal variation in the incidence of the disease, with two peaks in January and the summer months when viral and bacterial infections, respectively, are prevalent. Failure to thrive and low admission-weight percentiles were associated with methemoglobinemia in most of the patients and diarrhea lasting > or = 7 days in 22 (49%) patients. The blood pH and the degree of acidosis did not correlate with the severity of methemoglobinemia. All the patients were formula fed. In the etiology of methemoglobinemia in infants with enteritis, viral and bacterial pathogens appear to play an important role by altering intestinal flora. Breast feeding appears to protect against this entity.
A Hanukoglu; P N Danon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  23     ISSN:  0277-2116     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-12-16     Completed Date:  1996-12-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Department of Pediatrics, E. Wolfson Medical Center, Holon, Israel.
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MeSH Terms
Acidosis / blood
Bacteremia / microbiology
Bacteriuria / microbiology
Breast Feeding
Diarrhea, Infantile / blood,  complications*,  epidemiology
Feces / microbiology
Hydrogen-Ion Concentration
Infant Food
Infant, Newborn
Linear Models
Methemoglobinemia / blood,  complications*,  epidemiology
Milk Hypersensitivity / complications
Prospective Studies

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