Document Detail

Endogenous inhibitors of the Na,K pump.
MedLine Citation:
PMID:  8933501     Owner:  NLM     Status:  MEDLINE    
Evidence for a 'third factor' in the regulation of urinary sodium excretion has directed a search for a natriuretic agent which functions by inhibition of Na,K-ATPase. Such an agent may also be involved in the genesis of hypertension and provide an important pathophysiological link between increased sodium intake, reduced renal sodium excretory capacity and hypertension. Numerous lines of evidence have been developed, all supporting the possibility that third factor sodium pump inhibition may take place through the cardiac glycoside-binding site of the sodium pump. Inhibition of the sodium pump may contribute to renal mechanisms of sodium balance. Generalization of this inhibition to vascular tissue and to the neural tissue regulating vascular contraction may elevate blood pressure (and increase natriuresis) by increasing contraction. In spite of 30 years of effort, no convincing substance has been successfully identified as both a cardiac glycoside-like inhibitor of the sodium pump and an endogenous substance. However, recent work has led to the emergence and investigation of a number of interesting candidates. This review will survey the historical background of endogenous sodium pump inhibitors, examine some of the problems and requirements which must be overcome in their identification, analyze evidence obtained recently concerning a number of candidate compounds and identify problems which remain to be addressed in this field.
P A Doris
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Mineral and electrolyte metabolism     Volume:  22     ISSN:  0378-0392     ISO Abbreviation:  Miner Electrolyte Metab     Publication Date:  1996  
Date Detail:
Created Date:  1997-03-13     Completed Date:  1997-03-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7802196     Medline TA:  Miner Electrolyte Metab     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  303-10     Citation Subset:  IM    
Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock 79430, USA.
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MeSH Terms
Ascorbic Acid / pharmacology
Enzyme Inhibitors / metabolism*
Hypertension / metabolism
Ouabain / pharmacology
Sodium / urine
Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors*,  metabolism
Grant Support
Reg. No./Substance:
0/Enzyme Inhibitors; 50-81-7/Ascorbic Acid; 630-60-4/Ouabain; 7440-23-5/Sodium; EC ATPase

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