Document Detail

Endogenous hydrogen sulfide formation mediates the liver damage in endotoxemic rats.
MedLine Citation:
PMID:  23151462     Owner:  NLM     Status:  Publisher    
BACKGROUND: Hydrogen sulfide (H(2)S) is a naturally occurring gaseous transmitter and may play important roles in normal physiology and liver disease. AIMS: To investigate the relationships between the formation of liver H(2)S and liver damage in endotoxemic rats caused by lipopolysaccharide (LPS). METHODS: Male SD rats were sacrificed to acute endotoxemia and pretreated with H(2)S donor sodium hydrogen sulfide (NaHS) or H(2)S inhibitor dl-propargylglycine (PAG). Liver H(2)S concentration, liver cystathionine-γ-lyase (CSE) mRNA, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) level, liver histopathological alteration in different time after treatment were determined. RESULTS: Endotoxemia resulted in an increase in serum levels of ALT and AST. In the liver, endotoxemia induced a significant increase in the H(2)S concentration, and in the expression of the H(2)S-synthesizing enzymes CSE. Pretreatment with NaHS promoted the increase the liver H(2)S concentration and aggravated the LPS-induced liver damage, However, administration of PAG abolished the increase the liver H(2)S concentration and reduced the liver injury caused by endotoxemia. CONCLUSIONS: These findings support the view that an enhanced formation of H(2)S contributes to the liver injury in endotoxemia. We propose that inhibition of H(2)S synthesis may be a useful the rapeutic strategy against the liver injury associated with endotoxemia.
Yulin Yan; Chao Chen; Hui Zhou; Hong Gao; Liping Chen; Ling Chen; Libo Gao; Ru Zhao; Yongke Sun
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-11
Journal Detail:
Title:  Research in veterinary science     Volume:  -     ISSN:  1532-2661     ISO Abbreviation:  Res. Vet. Sci.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401300     Medline TA:  Res Vet Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
College of Animal Science and Technology, Yunnan Agricultural University, Kunming, PR China. Electronic address:
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