Document Detail


Endogenous glutamate in association with inflammatory and hormonal factors modulates bone tissue resorption of the temporomandibular joint in patients with early rheumatoid arthritis.
MedLine Citation:
PMID:  19686927     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The aim of this study was to investigate the relation between plasma level of glutamate and extent of radiographic bone erosion of the temporomandibular joint (TMJ) in patients with early rheumatoid arthritis (RA) in relation to inflammatory disease activity as well as estradiol and testosterone.
MATERIALS AND METHODS: A total of 47 patients (29 women and 18 men) of whom 24 were seropositive were included shortly after being diagnosed with RA. Radiographic signs of bone tissue resorption (erosions) in the TMJ were recorded by cone-beam CT images, and an erosion score (0 to 24) was calculated for each patient. Venous blood was analyzed for rheumatoid factor, C-reactive protein, erythrocyte sedimentation rate, leukocyte particle count, glutamate, estradiol, and testosterone. Nonparametric statistical methods were used in the analysis.
RESULTS: Resorptive changes of the TMJ were found in a major part of the patients. There was a significant positive correlation between plasma level of glutamate and extension of radiographic erosions that was strongest in the patients with low levels of C-reactive protein, estradiol, or testosterone. By contrast, erosions were correlated with C-reactive protein in patients with high levels of estradiol. The highest levels of glutamate were found in patients with low levels of C-reactive protein and estradiol.
CONCLUSIONS: This study shows that a majority of patients with early RA presents radiographic signs of bone tissue resorption of the TMJ and that circulating glutamate is associated with the extent of these changes. The relationship between glutamate and bone resorption seems to be influenced by systemic inflammatory activity as well as estradiol and testosterone levels.
Authors:
Anna-Kari Hajati; Per Alstergren; Karin Näsström; Johan Bratt; Sigvard Kopp
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons     Volume:  67     ISSN:  1531-5053     ISO Abbreviation:  J. Oral Maxillofac. Surg.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-18     Completed Date:  2009-09-01     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  8206428     Medline TA:  J Oral Maxillofac Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1895-903     Citation Subset:  AIM; D; IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Arthritis, Rheumatoid / blood*,  pathology,  radiography
Blood Sedimentation
Bone Resorption / blood,  pathology*,  radiography
C-Reactive Protein / analysis
Cone-Beam Computed Tomography
Estradiol / blood*
Female
Glutamic Acid / blood*
Humans
Inflammation Mediators / blood
Leukocyte Count
Male
Middle Aged
Rheumatoid Factor / blood
Sex Factors
Temporomandibular Joint / pathology*,  radiography
Temporomandibular Joint Disorders / blood*,  pathology,  radiography
Testosterone / blood*
Grant Support
ID/Acronym/Agency:
R01 DE015420/DE/NIDCR NIH HHS; R01 DE015420-01/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/Inflammation Mediators; 3KX376GY7L/Glutamic Acid; 3XMK78S47O/Testosterone; 4TI98Z838E/Estradiol; 9007-41-4/C-Reactive Protein; 9009-79-4/Rheumatoid Factor
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