Document Detail

Endogenous ghrelin is an orexigenic peptide acting in the arcuate nucleus in response to fasting.
MedLine Citation:
PMID:  12609764     Owner:  NLM     Status:  MEDLINE    
Ghrelin, a circulating growth-hormone releasing peptide derived from stomach, stimulates food intake through neuropeptide Y (NPY) neurons of the arcuate nucleus in the hypothalamus (ARC). We examined the effect of ghrelin microinjected into the ARC and the influence of intracerebroventricular (i.c.v.) pretreatment with a GHRH or NPY receptor antagonist on ghrelin-induced food intake in free-feeding male rats. Ghrelin (0.1-1 microg) stimulated food intake in a dose-dependent manner, and this effect was reduced by 55-60% by the Y(5) NPY receptor antagonist (10 microg i.c.v.), but not by the GHRH receptor antagonist MZ-4-71 (10 microg i.c.v.). We also evaluated the effects of passive ghrelin immunoneutralization by the microinjection of anti-ghrelin immunoglobulins (IgGs) intracerebroventricularly or directly into the ARC on food intake in free-feeding and fasted male rats. i.c.v. administration of anti-ghrelin IgGs decreased cumulative food intake over 24 h, whereas microinfusion of anti-ghrelin IgGs into the ARC induced only a short-lived (2 and 6 h) effect. Collectively, these data would indicate that centrally derived ghrelin has a major role in the control of food intake in rats and, in this context, blood-born ghrelin would be effective only in relation to its ability to reach the ARC, which is devoid of blood-brain barrier.
Michela Bagnasco; Giovanni Tulipano; Maria R Melis; Antonio Argiolas; Daniela Cocchi; Eugenio E Muller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Regulatory peptides     Volume:  111     ISSN:  0167-0115     ISO Abbreviation:  Regul. Pept.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-02-28     Completed Date:  2003-11-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8100479     Medline TA:  Regul Pept     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  161-7     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Elsevier Science B.V.
Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Via Vanvitelli, 32-20129 Milan, Italy.
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MeSH Terms
Arcuate Nucleus / drug effects,  metabolism*
Dose-Response Relationship, Drug
Eating / physiology
Fasting / metabolism*
Growth Hormone-Releasing Hormone / antagonists & inhibitors
Immunoglobulin G / pharmacology
Injections, Intraventricular
Neuropeptide Y / antagonists & inhibitors
Peptide Hormones / immunology,  pharmacology*,  physiology
Rats, Sprague-Dawley
Receptors, Neuropeptide / antagonists & inhibitors
Sermorelin / analogs & derivatives*,  pharmacology
Reg. No./Substance:
0/Ghrelin; 0/Immunoglobulin G; 0/MZ 4-71; 0/Neuropeptide Y; 0/Peptide Hormones; 0/Receptors, Neuropeptide; 86168-78-7/Sermorelin; 9034-39-3/Growth Hormone-Releasing Hormone

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