Document Detail

Endogenous free radical generation may influence proteolysis in mitochondria.
MedLine Citation:
PMID:  3977904     Owner:  NLM     Status:  MEDLINE    
Isolated Mitochondria were allowed to incorporate radioactive amino acids into protein and proteolysis was then measured. In State 4 free radical generation was manipulated by means of respiratory chain blockers and uncouplers. Conditions of enhanced radical flux resulted in accelerated protein breakdown. We suggest that radicals influence proteolysis in cells both directly (by fragmenting proteins) and indirectly (by rendering proteins more susceptible to proteinases).
R T Dean; J K Pollak
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  126     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1985 Feb 
Date Detail:
Created Date:  1985-04-03     Completed Date:  1985-04-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1082-9     Citation Subset:  IM    
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MeSH Terms
Amino Acids / metabolism
Free Radicals*
Lysosomes / metabolism
Mitochondria, Liver / metabolism*
Oxygen Consumption
Protein Biosynthesis
Proteins / metabolism*
Reg. No./Substance:
0/Amino Acids; 0/Free Radicals; 0/Proteins

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