Document Detail

Endogenous excitatory amino acid neurotransmission regulates thyroid-stimulating hormone and thyroid hormone secretion in conscious freely moving male rats.
MedLine Citation:
PMID:  12108519     Owner:  NLM     Status:  MEDLINE    
The role of neurotransmission of endogenous excitatory amino acid (EAA) on serum thyroid hormones and thyroid-stimulating hormone (TSH) levels was examined in conscious and freely moving adult male Sprague-Dawley rats. The rats were cannulated at the third ventricle 2 d before the experiments. Several glutamate receptor agonists, such as kainic acid and domoic acid, and antagonists, such as 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and dizocilpine (MK-801) were administered into the third ventricle. Serum TSH levels were assesed by radioimmunoassay, and serum thyroid hormone levels were assessed by enzyme immunoassay. The results showed that the administration of CNQX and MK-801 produced a decrease in serum levels of TSH and thyroid hormones. The administration of kainic acid and domoic acid increased TSH concentrations, whereas CNQX completely blocked the release of TSH induced by kainic acid and domoic acid. These results suggest the importance of endogenous EAA in the regulation of hormone secretion from the pituitary-thyroid axis, as well as the role of the N-methyl-D-aspartate (NMDA) and non-NMDA receptors in the stimulatory effect of EAAs on the pituitary-thyroid axis.
M C Arufe; R Dur?n; D Perez-Vences; M Alfonso
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Endocrine     Volume:  17     ISSN:  1355-008X     ISO Abbreviation:  Endocrine     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-07-10     Completed Date:  2002-12-24     Revised Date:  2010-06-24    
Medline Journal Info:
Nlm Unique ID:  9434444     Medline TA:  Endocrine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  193-7     Citation Subset:  IM    
Departamento de Biolog?a Funcional y Ciencias de la Salud, Area de Fisiolog?a, Facultad de Ciencias, Universidad de Vigo, Spain.
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MeSH Terms
6-Cyano-7-nitroquinoxaline-2,3-dione / pharmacology
Area Under Curve
Dizocilpine Maleate / pharmacology
Excitatory Amino Acid Antagonists / pharmacology
Excitatory Amino Acids / physiology*
Injections, Intraventricular
Kainic Acid / administration & dosage,  pharmacology
Rats, Sprague-Dawley
Receptors, AMPA / antagonists & inhibitors
Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors
Synaptic Transmission / physiology*
Thyroid Hormones / metabolism*
Thyrotropin / metabolism*
Thyroxine / blood
Triiodothyronine / blood
Reg. No./Substance:
0/Excitatory Amino Acid Antagonists; 0/Excitatory Amino Acids; 0/Receptors, AMPA; 0/Receptors, N-Methyl-D-Aspartate; 0/Thyroid Hormones; 115066-14-3/6-Cyano-7-nitroquinoxaline-2,3-dione; 487-79-6/Kainic Acid; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 77086-22-7/Dizocilpine Maleate; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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