| Endogenous erythropoietin as part of the cytokine network in the pathogenesis of experimental autoimmune encephalomyelitis. | |
| | |
MedLine Citation:
|
PMID: 18670620 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Erythropoietin (EPO) is of great interest as a therapy for many of the central nervous system (CNS) diseases and its administration is protective in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Endogenous EPO is induced by hypoxic/ischemic injury, but little is known about its expression in other CNS diseases. We report here that EPO expression in the spinal cord is induced in mouse models of chronic or relapsing-remitting EAE, and is prominently localized to motoneurons. We found a parallel increase of hypoxia-inducible transcription factor (HIF)-1 alpha, but not HIF-2 alpha, at the mRNA level, suggesting a possible role of non-hypoxic factors in EPO induction. EPO mRNA in the spinal cord was co-expressed with interferon (IFN)-gamma and tumor necrosis factor (TNF), and these cytokines inhibited EPO production in vitro in both neuronal and glial cells. Given the known inhibitory effect of EPO on neuroinflammation, our study indicates that EPO should be viewed as part of the inflammatory/anti-inflammatory network in MS. |
| | |
Authors:
|
Manuela Mengozzi; Ilaria Cervellini; Paolo Bigini; Sara Martone; Antonella Biondi; Rosetta Pedotti; Barbara Gallo; Sara Barbera; Tiziana Mennini; Mariaserena Boraso; Marina Marinovich; Edwige Petit; Myriam Bernaudin; Roberto Bianchi; Barbara Viviani; Pietro Ghezzi |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-07-30 |
Journal Detail:
|
Title: Molecular medicine (Cambridge, Mass.) Volume: 14 ISSN: 1528-3658 ISO Abbreviation: Mol. Med. Publication Date: 2008 Nov-Dec |
Date Detail:
|
Created Date: 2008-11-14 Completed Date: 2009-05-12 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 9501023 Medline TA: Mol Med Country: United States |
Other Details:
|
Languages: eng Pagination: 682-8 Citation Subset: IM |
Affiliation:
|
Mario Negri Institute for Pharmacological Research, Milan, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cell Line, Tumor Cytokines / metabolism* Encephalomyelitis, Autoimmune, Experimental / metabolism* Erythropoietin / genetics, metabolism*, physiology* Female Gene Expression / drug effects Humans Hypoxia-Inducible Factor 1, alpha Subunit / genetics Immunohistochemistry Interferon-gamma / pharmacology Mice Reverse Transcriptase Polymerase Chain Reaction Spinal Cord / metabolism Tumor Necrosis Factor-alpha / pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Cytokines; 0/Hif1a protein, mouse; 0/Hypoxia-Inducible Factor 1, alpha Subunit; 0/Tumor Necrosis Factor-alpha; 11096-26-7/Erythropoietin; 82115-62-6/Interferon-gamma |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Angiogenesis and diabetes: different responses to pro-angiogenic factors in the chorioallantoic memb...
Next Document: Role of C-Peptide in the regulation of microvascular blood flow.