Document Detail


Endogenous erythroid colony formation in patients with retinal vein occlusion.
MedLine Citation:
PMID:  18054634     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The pathophysiology and causes of retinal vein occlusion (RVO) remain largely unknown. Latent forms of myeloproliferative disorders, which are diagnosed by the presence of in vitro endogenous erythroid colony (EEC) formation, are a well-known cause of intraabdominal vein thrombosis. The suspected diagnosis of a latent myeloproliferative disorder in a patient with RVO, based on the presence of EEC formation, led us to evaluate the association between latent myeloproliferative disorders and RVO.
DESIGN: Observational case series in a national eye center.
PARTICIPANTS: Forty-four patients, with a mean age of 46 years (range, 21-62) and central (n = 38) or peripheral (n = 6) RVO responsible for visual acuity decreased to 6/12 or less.
METHODS: In vitro bone marrow culture.
MAIN OUTCOME MEASURE: Endogenous erythroid colony formation in cytokine-free culture medium. Conventional diagnostic criteria for myeloproliferative disorders and the JAK2 V617F mutation (which is strongly associated with myeloproliferative disorders) were assessed in RVO patients showing EECs.
RESULTS: Endogenous erythroid colony formation was observed in 12 of 44 (27%) patients with RVO, 13 of 35 (37%) patients with Budd-Chiari syndrome, and 52 of 53 (98%) patients with primary polycythemia (positive control groups) but not in 22 healthy bone marrow donors (negative controls) evaluated at the same time and by the same hematology laboratory. Neither conventional nor genetic diagnostic criteria for myeloproliferative disorders were observed in any patient with both RVO and an EEC at the time of diagnosis or during follow-up.
CONCLUSIONS: Endogenous erythroid colony formation is frequently observed in patients with RVO independently of any detectable myeloproliferative disorder. This opens a new aspect of research on the pathophysiology of this sight-threatening disease.
Authors:
Emmanuel Héron; Christophe Marzac; Sylvie Feldman-Billard; Jean-François Girmens; Michel Paques; Richard Delarue; Jean-Charles Piette; Nicole Casadevall; Olivier Hermine
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ophthalmology     Volume:  114     ISSN:  1549-4713     ISO Abbreviation:  Ophthalmology     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-06     Completed Date:  2007-12-18     Revised Date:  2012-06-05    
Medline Journal Info:
Nlm Unique ID:  7802443     Medline TA:  Ophthalmology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2155-61     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris, France. heron@quinze-vingts.fr
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MeSH Terms
Descriptor/Qualifier:
Adult
Bone Marrow
Budd-Chiari Syndrome / blood
Colony-Forming Units Assay
Erythroid Cells*
Erythropoiesis / physiology
Female
Humans
Janus Kinase 2 / genetics
Male
Middle Aged
Point Mutation
Polycythemia Vera / blood*,  genetics,  physiopathology
Retinal Vein Occlusion / blood*,  physiopathology
Visual Acuity
Chemical
Reg. No./Substance:
EC 2.7.10.1/Janus Kinase 2; EC 2.7.10.2/JAK2 protein, human

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