| Endogenous erythroid colony formation in patients with retinal vein occlusion. | |
| | |
MedLine Citation:
|
PMID: 18054634 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: The pathophysiology and causes of retinal vein occlusion (RVO) remain largely unknown. Latent forms of myeloproliferative disorders, which are diagnosed by the presence of in vitro endogenous erythroid colony (EEC) formation, are a well-known cause of intraabdominal vein thrombosis. The suspected diagnosis of a latent myeloproliferative disorder in a patient with RVO, based on the presence of EEC formation, led us to evaluate the association between latent myeloproliferative disorders and RVO. DESIGN: Observational case series in a national eye center. PARTICIPANTS: Forty-four patients, with a mean age of 46 years (range, 21-62) and central (n = 38) or peripheral (n = 6) RVO responsible for visual acuity decreased to 6/12 or less. METHODS: In vitro bone marrow culture. MAIN OUTCOME MEASURE: Endogenous erythroid colony formation in cytokine-free culture medium. Conventional diagnostic criteria for myeloproliferative disorders and the JAK2 V617F mutation (which is strongly associated with myeloproliferative disorders) were assessed in RVO patients showing EECs. RESULTS: Endogenous erythroid colony formation was observed in 12 of 44 (27%) patients with RVO, 13 of 35 (37%) patients with Budd-Chiari syndrome, and 52 of 53 (98%) patients with primary polycythemia (positive control groups) but not in 22 healthy bone marrow donors (negative controls) evaluated at the same time and by the same hematology laboratory. Neither conventional nor genetic diagnostic criteria for myeloproliferative disorders were observed in any patient with both RVO and an EEC at the time of diagnosis or during follow-up. CONCLUSIONS: Endogenous erythroid colony formation is frequently observed in patients with RVO independently of any detectable myeloproliferative disorder. This opens a new aspect of research on the pathophysiology of this sight-threatening disease. |
| | |
Authors:
|
Emmanuel Héron; Christophe Marzac; Sylvie Feldman-Billard; Jean-François Girmens; Michel Paques; Richard Delarue; Jean-Charles Piette; Nicole Casadevall; Olivier Hermine |
Related Documents
:
|
21931084 - Prevalence of occult nostril asymmetry in the oversized nasal tip: a quantitative photo... 2681494 - Hematologic abnormalities in patients with the acquired immunodeficiency syndrome. a co... 1732234 - High calcitonin levels in unconscious polytrauma patients. 16830204 - Osteoprotegerin and bone mass in squamous cell head and neck cancer patients. 20413984 - The angiotensinogen agt p.m235t gene polymorphism may be responsible for the developmen... 2446274 - Intermittent ventricular standstill during chronic atrial fibrillation in patients with... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Ophthalmology Volume: 114 ISSN: 1549-4713 ISO Abbreviation: Ophthalmology Publication Date: 2007 Dec |
Date Detail:
|
Created Date: 2007-12-06 Completed Date: 2007-12-18 Revised Date: 2012-06-05 |
Medline Journal Info:
|
Nlm Unique ID: 7802443 Medline TA: Ophthalmology Country: United States |
Other Details:
|
Languages: eng Pagination: 2155-61 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris, France. heron@quinze-vingts.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Bone Marrow Budd-Chiari Syndrome / blood Colony-Forming Units Assay Erythroid Cells* Erythropoiesis / physiology Female Humans Janus Kinase 2 / genetics Male Middle Aged Point Mutation Polycythemia Vera / blood*, genetics, physiopathology Retinal Vein Occlusion / blood*, physiopathology Visual Acuity |
| Chemical | |
Reg. No./Substance:
|
EC 2.7.10.1/Janus Kinase 2; EC 2.7.10.2/JAK2 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Scleral buckling versus primary vitrectomy in rhegmatogenous retinal detachment: a prospective rando...
Next Document: Association of complement factor H and LOC387715 genotypes with response of exudative age-related ma...