Document Detail

Endogenous dopamine (DA) and DA2 receptors: a mechanism limiting excessive sympathetic-adrenal discharge in humans.
MedLine Citation:
PMID:  3280589     Owner:  NLM     Status:  MEDLINE    
We studied the effects of presynaptic dopamine (DA) 2 receptor blockade on the sympathetic-adrenal response to graded exercise in seven normal men. DA2 receptor blockade was achieved by means of domperidone (DMP) administration. The exercise consisted of progressive cycling activity, from 30-80% of the predetermined maximal oxygen consumption for each man. Systolic, diastolic, and mean arterial pressures; heart rate; and plasma norepinephrine (NE), epinephrine (E), PRL, glucose, lactate, FFA, sodium, potassium, cortisol, and PRA were measured at rest, during exercise, and during recovery after placebo or DMP administration. Graded exercise caused significant increases in systolic and mean arterial pressures and plasma NE, E, lactate, sodium, potassium, FFA, cortisol, and PRA. DMP administration before exercise caused a significant increase in plasma PRL (P = 0.0009), a greater increase in plasma NE at the end of the exercise (P = 0.002), and an overall increase in plasma E (P = 0.02) and FFA (P = 0.02) concentrations. These results strongly suggest that endogenous DA limits catecholamine release during sympathetic-adrenal stimulation by activating DA2 receptors.
M Mannelli; C Pupilli; G Fabbri; R Musante; M L De Feo; F Franchi; G Giusti
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  66     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-05-12     Completed Date:  1988-05-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  626-31     Citation Subset:  AIM; IM    
Endocrinology Service USL 10/D, Florence, Italy.
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MeSH Terms
Adrenal Glands / physiology*
Blood Glucose / analysis
Blood Pressure
Domperidone / pharmacology
Epinephrine / blood
Fatty Acids, Nonesterified / blood
Heart Rate
Hydrocortisone / blood
Lactates / blood
Lactic Acid
Norepinephrine / blood
Physical Exertion
Potassium / blood
Prolactin / blood
Receptors, Dopamine / physiology*
Reference Values
Renin / blood
Sodium / blood
Sympathetic Nervous System / physiology*
Reg. No./Substance:
0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Lactates; 0/Receptors, Dopamine; 50-21-5/Lactic Acid; 50-23-7/Hydrocortisone; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 57808-66-9/Domperidone; 7440-09-7/Potassium; 7440-23-5/Sodium; 9002-62-4/Prolactin; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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