Document Detail


Endogenous digitalis-like factors: their possible pathophysiological implications with particular regard to the perinatal period.
MedLine Citation:
PMID:  1962738     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Endogenous factors with biological and immunological activity similar to cardiac glycoside drugs (endogenous digitalis-like factors; EDLF) have been found in several tissues and body fluids of animals and humans. Detectable EDLF concentrations were found in blood and urine extracts of adults (normal healthy controls, hypertensive patients and salt-loaded healthy subjects), while higher levels were generally observed in plasma samples of pregnant women, newborns, and patients with renal insufficiency. The chemical characteristics of this endogenous factor are, at present, unknown, although it has been suggested that EDLF could be a substance with low molecular weight. Experimental studies and theoretical considerations suggest that EDLF, in addition to the ability to react with antibodies, might also bind to the specific cellular receptor of the cardiac glycosides and thus inhibit the membrane Na+/K(+)-ATPase (sodium pump). Therefore, it has been suggested that EDLF is an endogenous modulator of the membrane sodium-potassium pump, and that it could play a role in the regulation of fluids and electrolytes, in the myocardial muscular tone and also in the pathogenesis of hypertension.
Authors:
P Biver; A Clerico; A Paci; S Balzan; A Boldrini; C Cipolloni
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Child nephrology and urology     Volume:  10     ISSN:  1012-6694     ISO Abbreviation:  Child Nephrol Urol     Publication Date:  1990  
Date Detail:
Created Date:  1991-03-28     Completed Date:  1991-03-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8910177     Medline TA:  Child Nephrol Urol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  164-80     Citation Subset:  IM    
Affiliation:
U.O. Neonatologia, Cattedra di Neonatologia, Università di Pisa, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Proteins* / isolation & purification,  physiology
Cardenolides
Digoxin*
Female
Humans
Hypertension / etiology,  metabolism
Infant, Newborn
Kidney Diseases / metabolism
Pregnancy
Pregnancy Complications, Cardiovascular / metabolism
Saponins*
Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors*
Water-Electrolyte Balance / physiology
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Cardenolides; 0/Saponins; 0/digoxin-like factors; 20830-75-5/Digoxin; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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