| Endogenous cholecystokinin enhances postprandial gastroesophageal reflux in humans through extrasphincteric receptors. | |
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MedLine Citation:
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PMID: 9721157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND & AIMS: Exogenous cholecystokinin (CCK) decreases lower esophageal sphincter (LES) pressure and increases transient LES relaxations (TLESRs) in humans. The aims of this study were to determine whether endogenous CCK increases gastroesophageal reflux in humans and whether this is a direct effect on the LES. METHODS: Esophageal pH, LES pressure, and gallbladder volume were measured in 8 healthy volunteers after ingestion of a 181-kcal meal alone or adding 12 g cholestyramine to increase endogenous CCK release. In 7 additional volunteers, the effect of cholestyramine was studied during intravenous perfusion of saline or the CCK-A receptor antagonist loxiglumide. In circular LES strips from 9 transplant donors, we measured the effect of CCK-8 (10(-11) to 3 x 10(-8) mol/L) on basal tension and on electrical field-induced relaxation. RESULTS: Cholestyramine increased gallbladder emptying, reflux episodes, TLESRs, and time of esophageal pH of <4. Loxiglumide inhibited postprandial gallbladder emptying, reflux episodes, TLESRs, and time of pH of <4 and prevented the decrease in LES pressure induced by cholestyramine. In vitro, CCK-8 contracted LES strips through a tetrodotoxin-insensitive pathway but did not modify electrical field-induced LES relaxations. CONCLUSIONS: Endogenous CCK enhances postprandial gastroesophageal reflux in humans by increasing the rate of TLESRs and reduces postprandial LES pressure. These actions seem mediated by extrasphincteric CCK-A receptors that override a direct contractile effect of CCK on the LES muscle. |
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Authors:
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P Clavé; A González; A Moreno; R López; A Farré; X Cussó; M D'Amato; F Azpiroz; F Lluís |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Gastroenterology Volume: 115 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1998 Sep |
Date Detail:
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Created Date: 1998-09-16 Completed Date: 1998-09-16 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 597-604 Citation Subset: AIM; IM |
Affiliation:
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Laboratori d'Investigació Gastrointestinal, Institut de Recerca, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cholecystokinin / physiology*, secretion Cholestyramine Resin / pharmacology* Eating Electric Stimulation Esophagogastric Junction / drug effects, physiology*, physiopathology Esophagus / drug effects, physiology*, physiopathology Gallbladder / physiology Gastroesophageal Reflux / physiopathology* Humans Hydrogen-Ion Concentration Male Muscle Contraction / drug effects Muscle Relaxation / drug effects Muscle, Smooth / drug effects, physiology Proglumide / analogs & derivatives*, pharmacology Receptor, Cholecystokinin A Receptors, Cholecystokinin / antagonists & inhibitors, physiology* Sincalide / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Receptor, Cholecystokinin A; 0/Receptors, Cholecystokinin; 107097-80-3/loxiglumide; 11041-12-6/Cholestyramine Resin; 25126-32-3/Sincalide; 6620-60-6/Proglumide; 9011-97-6/Cholecystokinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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