| Endogenous cardiotonic steroids and salt-sensitive hypertension. | |
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MedLine Citation:
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PMID: 20347967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endogenous cardiotonic steroids (CTS), also called digitalis like factors, have been postulated to play important roles in pathogenesis of hypertension for nearly half of a century. For the past 50 years biomedical scientists have been in quest of an unidentified factor or hormone that both increases blood pressure and renal sodium excretion; this "natriuretic hormone" was, in fact, postulated to interact with the Na/K-ATPase. Recent discoveries have led to the identification of steroid molecules which are present in humans, rodents and amphibians, and which, in a complex manner, interact with each other and with the other systems that regulate renal salt handling and contribute to the salt-sensitivity of blood pressure. Recent findings include the specific identification of endogenous cardenolide (endogenous ouabain) and bufadienolide (marinobufagenin) CTS in humans along with the delineation of mechanisms by which CTS can signal through the Na/K-ATPase. Although CTS were first considered important in the regulation of renal sodium transport and arterial pressure, more recent work implicates these hormones in the central regulation of blood pressure and regulation of cell growth, and development of cardiovascular and renal fibrosis in particular. |
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Authors:
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Olga V Fedorova; Joseph I Shapiro; Alexei Y Bagrov |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Review Date: 2010-03-27 |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 1802 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-01 Completed Date: 2010-12-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1230-6 Citation Subset: IM |
Copyright Information:
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Published by Elsevier B.V. |
Affiliation:
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National Institute on Aging, National Institutes of Health, Baltimore, MD, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amphibians Animals Biological Transport Blood Pressure Fibrosis / metabolism, pathology, physiopathology Humans Hypertension / metabolism*, pathology, physiopathology Kidney / metabolism*, pathology, physiopathology Kidney Diseases / metabolism, pathology, physiopathology Ouabain / metabolism* Rodentia Sodium / metabolism* Sodium-Potassium-Exchanging ATPase / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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HL071556/HL/NHLBI NIH HHS; ZIA AG000609-17/AG/NIA NIH HHS; ZIA AG000868-02/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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630-60-4/Ouabain; 7440-23-5/Sodium; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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