Document Detail

Endogenous cardiotonic steroids and salt-sensitive hypertension.
MedLine Citation:
PMID:  20347967     Owner:  NLM     Status:  MEDLINE    
Endogenous cardiotonic steroids (CTS), also called digitalis like factors, have been postulated to play important roles in pathogenesis of hypertension for nearly half of a century. For the past 50 years biomedical scientists have been in quest of an unidentified factor or hormone that both increases blood pressure and renal sodium excretion; this "natriuretic hormone" was, in fact, postulated to interact with the Na/K-ATPase. Recent discoveries have led to the identification of steroid molecules which are present in humans, rodents and amphibians, and which, in a complex manner, interact with each other and with the other systems that regulate renal salt handling and contribute to the salt-sensitivity of blood pressure. Recent findings include the specific identification of endogenous cardenolide (endogenous ouabain) and bufadienolide (marinobufagenin) CTS in humans along with the delineation of mechanisms by which CTS can signal through the Na/K-ATPase. Although CTS were first considered important in the regulation of renal sodium transport and arterial pressure, more recent work implicates these hormones in the central regulation of blood pressure and regulation of cell growth, and development of cardiovascular and renal fibrosis in particular.
Olga V Fedorova; Joseph I Shapiro; Alexei Y Bagrov
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Review     Date:  2010-03-27
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1802     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-01     Completed Date:  2010-12-21     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1230-6     Citation Subset:  IM    
Copyright Information:
Published by Elsevier B.V.
National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
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MeSH Terms
Biological Transport
Blood Pressure
Fibrosis / metabolism,  pathology,  physiopathology
Hypertension / metabolism*,  pathology,  physiopathology
Kidney / metabolism*,  pathology,  physiopathology
Kidney Diseases / metabolism,  pathology,  physiopathology
Ouabain / metabolism*
Sodium / metabolism*
Sodium-Potassium-Exchanging ATPase / metabolism
Grant Support
Reg. No./Substance:
630-60-4/Ouabain; 7440-23-5/Sodium; EC ATPase

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