| Endogenous carbon monoxide production correlates weakly with severity of acute illness. | |
| | |
MedLine Citation:
|
PMID: 16426465 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND OBJECTIVE: The enzyme haeme oxygenase-1 is highly inducible by oxidative agents. Its product carbon monoxide is thought to exert anti-inflammatory properties. We recently showed, that critically ill patients produce higher amounts of carbon monoxide compared to healthy controls. In the present study we compare endogenous carbon monoxide production with the severity of illness of intensive care unit patients. METHODS: Exhaled carbon monoxide concentration was measured in 95 mechanically ventilated, critically ill patients (mean age +/- SD, 59.5 +/- 15.7) on a carbon monoxide monitor. Measurements were taken every hour for 24 h in each patient. Data were analysed using Mann-Whitney rank sum test. Correlation analysis was performed with the Spearman's rank order correlation. RESULTS: Carbon monoxide production correlated weakly with the multiple organ dysfunction score (R = 0.27; P = 0.009). Patients suffering from cardiac disease (median 22.5, interquartile range 16.2-27.4 microL kg(-1) h(-1) vs. median 18.2, interquartile range 14.2-21.8 microL kg(-1) h(-1), P = 0.008) and critically ill patients undergoing dialysis (median 25.0, interquartile range 21.4-30.2 microL kg(-1) h(-1), vs. median 19.4, interquartile range 14.7-23.3 microL kg(-1) h(-1), P = 0.004) produced significantly higher amounts of carbon monoxide compared to critically ill controls. CONCLUSION: The findings suggest that endogenous carbon monoxide production might reflect the severity of acute organ dysfunction. |
| | |
Authors:
|
M Scharte; T A von Ostrowski; F Daudel; H Freise; H Van Aken; H G Bone |
Related Documents
:
|
9554645 - Use of a pulse oximeter in an adult emergency department: impact on the number of arter... 8268575 - Extracorporeal membrane oxygenation for adult post cardiotomy cardiogenic shock using a... 3965735 - Hypertonic lactated saline resuscitation of severely burned patients over 60 years of age. 3178485 - Effect of bacteremia on mortality after thermal injury. 6485745 - Lymphocytapheresis therapy in multiple sclerosis, a preliminary study. 7722265 - Tardy ulnar nerve palsy caused by cubitus varus deformity. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: European journal of anaesthesiology Volume: 23 ISSN: 0265-0215 ISO Abbreviation: Eur J Anaesthesiol Publication Date: 2006 Feb |
Date Detail:
|
Created Date: 2006-01-23 Completed Date: 2006-05-16 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8411711 Medline TA: Eur J Anaesthesiol Country: England |
Other Details:
|
Languages: eng Pagination: 117-22 Citation Subset: IM |
Affiliation:
|
Universitätsklinikum Münster, Klinik und Poliklinik für Anästhesiologie und Operative Intensivmedizin, Muenster, Germany. scharte@anit.uni-muenster.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
APACHE* Breath Tests Carbon Monoxide / analysis, metabolism* Cardiovascular Diseases / metabolism Critical Illness / classification* Female Humans Intensive Care Units Male Middle Aged Multiple Organ Failure / metabolism Respiration, Artificial |
| Chemical | |
Reg. No./Substance:
|
630-08-0/Carbon Monoxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Djinn Lite: a tool for customised gene transcript modelling, annotation-data enrichment and explorat...
Next Document: Isoflurane and sevoflurane during reperfusion prevent recovery from ischaemia in mitochondrial KATP ...