| Endogenous cannabinoid signaling is required for voluntary exercise-induced enhancement of progenitor cell proliferation in the hippocampus. | |
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MedLine Citation:
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PMID: 19489006 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Voluntary exercise and endogenous cannabinoid activity have independently been shown to regulate hippocampal plasticity. The aim of the current study was to determine whether the endocannabinoid system is regulated by voluntary exercise and if these changes contribute to exercise-induced enhancement of cell proliferation. In Experiment 1, 8 days of free access to a running wheel increased the agonist binding site density of the cannabinoid CB(1) receptor; CB(1) receptor-mediated GTPgammaS binding; and the tissue content of the endocannabinoid anandamide in the hippocampus but not in the prefrontal cortex. In Experiment 2, the CB(1) receptor antagonist AM251 (1 mg kg(-1)) was administered daily to animals given free access to a running wheel for 8 days, after which cell proliferation in the hippocampus was examined through immunohistochemical analysis of the cell cycle protein Ki-67. Voluntary exercise increased proliferation of progenitor cells, as evidenced by the increase in the number of Ki-67 positive cells in the granule cell layer of the dentate gyrus (DG) in the hippocampus. However, this effect was abrogated by concurrent treatment with AM251, indicating that the increase in endocannabinoid signaling in the hippocampus is required for the exercise-induced increase in cell proliferation. These data demonstrate that the endocannabinoid system in the hippocampus is sensitive to environmental change and suggest that it is a mediator of experience-induced plasticity. |
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Authors:
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Matthew N Hill; Andrea K Titterness; Anna C Morrish; Erica J Carrier; Tiffany T-Y Lee; Joana Gil-Mohapel; Boris B Gorzalka; Cecilia J Hillard; Brian R Christie |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hippocampus Volume: 20 ISSN: 1098-1063 ISO Abbreviation: Hippocampus Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-29 Completed Date: 2010-06-14 Revised Date: 2011-07-27 |
Medline Journal Info:
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Nlm Unique ID: 9108167 Medline TA: Hippocampus Country: United States |
Other Details:
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Languages: eng Pagination: 513-23 Citation Subset: IM |
Copyright Information:
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(c) 2009 Wiley-Liss, Inc. |
Affiliation:
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Department of Psychology, University of British Columbia, Vancouver, B.C., Canada. mhill@mail.rockefeller.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Cell Count Cell Cycle / physiology Cell Proliferation* Endocannabinoids / metabolism* Hippocampus / metabolism* Immunohistochemistry Neurogenesis Neurons / metabolism Physical Conditioning, Animal / physiology* Prefrontal Cortex / metabolism Radioligand Assay Rats Rats, Sprague-Dawley Receptor, Cannabinoid, CB1 / metabolism* Signal Transduction Stem Cells |
| Grant Support | |
ID/Acronym/Agency:
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R21 DA022439-02/DA/NIDA NIH HHS; R21DA022439/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Endocannabinoids; 0/Receptor, Cannabinoid, CB1 |
| Comments/Corrections | |
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