Document Detail


Endogenous bacterial flora in pregnant women and the influence of maternal genetic variation.
MedLine Citation:
PMID:  21054765     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Preterm labour, premature prelabour rupture of membranes and low birth weight have all been associated with either specific maternal genital tract infections or an altered vaginal microflora during pregnancy. Factors that influence the variation in microbial-host interaction play an important role in individual susceptibility to adverse pregnancy outcomes. The innate immune responses at mucosal surfaces play a crucial role against microbial invasion. Multiple genes are responsible for the regulation of the innate immune system. Genetic polymorphisms that disrupt innate immune recognition or the responses to infectious microorganisms could explain the alterations in microflora and individual susceptibility to pregnancy complications.
Authors:
M R Genc; A Onderdonk
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Publication Detail:
Type:  Journal Article     Date:  2010-11-04
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  118     ISSN:  1471-0528     ISO Abbreviation:  BJOG     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  154-63     Citation Subset:  AIM; IM    
Copyright Information:
© 2010 The Authors Journal compilation © RCOG 2010 BJOG An International Journal of Obstetrics and Gynaecology.
Affiliation:
Department of Obstetrics, Gynecology and Reproductive Biology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA. mrg2003@med.cornell.edu
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