Document Detail

Endogenous Pseudallescheria boydii endophthalmitis in a patient with ring-enhancing brain lesions.
MedLine Citation:
PMID:  11475400     Owner:  NLM     Status:  MEDLINE    
A 46-year-old man, status post liver transplantation and taking immunosuppressive medications, was admitted after suffering a generalized seizure. Magnetic resonance imaging of the brain revealed two ring-enhancing lesions and treatment was begun for presumed toxoplasmic encephalitis. He was already receiving amphotericin B for a skin lesion suspected to be caused by candidiasis. One day after the seizure, he complained of photophobia in the left eye. Intraocular inflammation and a small infiltrate in the macula were seen. Vision deteriorated over the next three days. Vitreous tap and injection of amphotericin B and vancomycin were performed, but the intraocular inflammation continued to increase. On day 15, a vitrectomy was performed. The vitreous specimen ultimately grew Pseudallescheria boydii. The patient died on hospital day 30 from complications of the brain abscesses. Pseudallescheria boydii should be considered in the differential diagnosis of endophthalmitis, especially in patients with immunosuppression, serious medical disease, or ring-enhancing brain lesions.
K K Luu; I U Scott; D Miller; J L Davis
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Ophthalmic surgery and lasers     Volume:  32     ISSN:  1082-3069     ISO Abbreviation:  Ophthalmic Surg Lasers     Publication Date:    2001 Jul-Aug
Date Detail:
Created Date:  2001-07-27     Completed Date:  2001-12-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9517132     Medline TA:  Ophthalmic Surg Lasers     Country:  United States    
Other Details:
Languages:  eng     Pagination:  325-9     Citation Subset:  IM    
Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, Florida 33136, USA.
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MeSH Terms
Brain / pathology
Brain Abscess / diagnosis,  drug therapy,  microbiology*
Diagnosis, Differential
Endophthalmitis / diagnosis,  drug therapy,  microbiology*
Eye Infections, Fungal / diagnosis,  drug therapy,  etiology*
Fatal Outcome
Immunocompromised Host
Immunosuppressive Agents / therapeutic use
Liver Transplantation
Magnetic Resonance Imaging
Middle Aged
Mycetoma / diagnosis,  drug therapy,  etiology*
Pseudallescheria / isolation & purification*
Visual Acuity
Vitreous Body / microbiology
Reg. No./Substance:
0/Immunosuppressive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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