Document Detail


Endogenous ouabain: a link between sodium intake and hypertension.
MedLine Citation:
PMID:  20972650     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The sodium pump, an ancestral enzyme with conserved ability to bind ouabain, plays a key role in salt conservation and is regulated by aldosterone and endogenous ouabain (EO). Plasma EO is elevated in about 45% of patients with essential hypertension and correlates with blood pressure. The relationship of EO with Na(+) balance is complex. Na(+) depletion raises circulating EO, whereas acute saline loads have no effect on EO in essential hypertension, and ambient levels of EO are unrelated to the saline sensitivity of blood pressure. Short-term periods of high dietary salt elevate EO and the relationship with salt balance in normal individuals is V-shaped, whereas the long-term relationship is likely to be L-shaped. Normal individuals suppress the high EO transient triggered by high-salt diets and avoid hypertension. In contrast, patients with elevated EO on normal Na(+) intakes have hypertension related to poor modulation of EO biosynthesis, clearance, or both.
Authors:
John M Hamlyn; Paolo Manunta
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current hypertension reports     Volume:  13     ISSN:  1534-3111     ISO Abbreviation:  Curr. Hypertens. Rep.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-04     Completed Date:  2011-05-04     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  100888982     Medline TA:  Curr Hypertens Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  14-20     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aldosterone / blood*
Diet
Humans
Hypertension / chemically induced*,  pathology
Nutritional Status
Ouabain / blood*
Receptors, Cell Surface*
Risk Factors
Sodium, Dietary / adverse effects*,  blood,  metabolism
Sodium-Potassium-Exchanging ATPase / blood*
Grant Support
ID/Acronym/Agency:
HL045215/HL/NHLBI NIH HHS; HL0788705/HL/NHLBI NIH HHS; HL75584/HL/NHLBI NIH HHS; R01 HL045215/HL/NHLBI NIH HHS; R01 HL045215-24/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Cell Surface; 0/Sodium, Dietary; 4964P6T9RB/Aldosterone; 5ACL011P69/Ouabain; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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