| Endogenous ouabain: a link between sodium intake and hypertension. | |
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MedLine Citation:
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PMID: 20972650 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The sodium pump, an ancestral enzyme with conserved ability to bind ouabain, plays a key role in salt conservation and is regulated by aldosterone and endogenous ouabain (EO). Plasma EO is elevated in about 45% of patients with essential hypertension and correlates with blood pressure. The relationship of EO with Na(+) balance is complex. Na(+) depletion raises circulating EO, whereas acute saline loads have no effect on EO in essential hypertension, and ambient levels of EO are unrelated to the saline sensitivity of blood pressure. Short-term periods of high dietary salt elevate EO and the relationship with salt balance in normal individuals is V-shaped, whereas the long-term relationship is likely to be L-shaped. Normal individuals suppress the high EO transient triggered by high-salt diets and avoid hypertension. In contrast, patients with elevated EO on normal Na(+) intakes have hypertension related to poor modulation of EO biosynthesis, clearance, or both. |
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Authors:
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John M Hamlyn; Paolo Manunta |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current hypertension reports Volume: 13 ISSN: 1534-3111 ISO Abbreviation: Curr. Hypertens. Rep. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-04 Completed Date: 2011-05-04 Revised Date: 2012-02-02 |
Medline Journal Info:
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Nlm Unique ID: 100888982 Medline TA: Curr Hypertens Rep Country: United States |
Other Details:
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Languages: eng Pagination: 14-20 Citation Subset: IM |
Affiliation:
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Department of Physiology, School of Medicine, University of Maryland, 655 West Baltimore Street, Baltimore, MD 21201, USA. jhamlyn@umaryland.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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blood* Diet Humans Hypertension / chemically induced*, pathology Nutritional Status Ouabain / blood* Receptors, Cell Surface* Risk Factors Sodium, Dietary / adverse effects*, blood, metabolism Sodium-Potassium-Exchanging ATPase / blood* |
| Grant Support | |
ID/Acronym/Agency:
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HL045215/HL/NHLBI NIH HHS; HL0788705/HL/NHLBI NIH HHS; HL75584/HL/NHLBI NIH HHS; R01 HL045215-24/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Cell Surface; 0/Sodium, Dietary; 52-39-1/Aldosterone; 630-60-4/Ouabain; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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