Document Detail


Endogenous opioids released during non-nociceptive environmental stress induce latent pain sensitization Via a NMDA-dependent process.
MedLine Citation:
PMID:  21723199     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PERSPECTIVE: Based on these preclinical data, it would be of clinical interest to evaluate whether prior stressful events may also affect further pain sensation in humans. Moreover, this preclinical model could be a good tool for evaluating new therapeutic strategies for relieving pain hypersensitivity.
Authors:
Chloé Le Roy; Emilie Laboureyras; Stéphanie Gavello-Baudy; Jérémy Chateauraynaud; Jean-Paul Laulin; Guy Simonnet
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-07-01
Journal Detail:
Title:  The journal of pain : official journal of the American Pain Society     Volume:  12     ISSN:  1528-8447     ISO Abbreviation:  J Pain     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-04     Completed Date:  2012-02-09     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  100898657     Medline TA:  J Pain     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1069-79     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Pain Society. Published by Elsevier Inc. All rights reserved.
Affiliation:
Université Bordeaux, INCIA, CNRS UMR 5287, F-33076 Bordeaux, France.
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MeSH Terms
Descriptor/Qualifier:
Analgesics, Opioid
Analysis of Variance
Animals
Carrageenan / toxicity
Disease Models, Animal
Excitatory Amino Acid Antagonists / pharmacology
Fentanyl
Hyperalgesia / etiology*
Inflammation / chemically induced,  complications
Ketamine / pharmacology
Male
Naltrexone
Narcotic Antagonists
Opioid Peptides / metabolism*
Pain Measurement
Pain Threshold / drug effects,  physiology*
Rats
Rats, Sprague-Dawley
Receptors, N-Methyl-D-Aspartate / metabolism*
Stress, Psychological / complications*
Swimming / psychology
Time Factors
Chemical
Reg. No./Substance:
0/Analgesics, Opioid; 0/Excitatory Amino Acid Antagonists; 0/Narcotic Antagonists; 0/Opioid Peptides; 0/Receptors, N-Methyl-D-Aspartate; 16590-41-3/Naltrexone; 437-38-7/Fentanyl; 6740-88-1/Ketamine; 9000-07-1/Carrageenan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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