Document Detail


Endogenous Oestradiol but Not Testosterone Is Related to Coronary Artery Disease in Men Sex hormones and coronary artery disease.
MedLine Citation:
PMID:  21521286     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objectives:  Men die of coronary artery disease more often (CAD) than women. There is evidence that testosterone is either neutral or has a beneficial effect on male cardiovascular disease. The role of oestrogens in male CAD has been less studied. This study was carried out with the purpose of evaluating the relationship between sex hormones levels and coronary artery disease. Designer:  Case-control study. Participants:  Men (aged 40-70) submitted to coronary angiography. A 70% occlusion of at least one major coronary artery defined the cases; subjects with ≤ 50% occlusion constituted the control group. Measurements:  Blood samples were collected for total testosterone, oestradiol, LH, FSH, SHBG, lipid profile and albumin measurements. Bioavailable and free testosterone, FAI and FEI were calculated. Oestradiol and total testosterone levels were examined as terciles, based on the whole study population. Results:  Of the 140 patients included, 72 were cases and 68 were controls. The baseline characteristics of the two groups were similar, except for the older age and lower LDL-C in the cases. Oestradiol and FEI but not total, bioavailable and free testosterone and FAI correlated positively with CAD. After adjustments for potential confounders oestradiol remained statistically significant. The prevalence of CAD was significantly higher in the 3(rd) than in the 1(st) tercile of oestradiol. Conclusion:  In this study, men with CAD had higher oestradiol and FEI levels. Additional studies are needed to clarify the direction of causality and possible underlying mechanisms.
Authors:
Emmanuela Quental Callou de Sá; Francisco Carleial Feijó de Sá; Rebeca de Souza E Silva; Kelly Cristina de Oliveira; Alexis Dourado Guedes; Fausto Feres; Ieda Therezinha do Nascimento Verreschi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-16
Journal Detail:
Title:  Clinical endocrinology     Volume:  -     ISSN:  1365-2265     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-4-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Blackwell Publishing Ltd.
Affiliation:
Division of Endocrinology, Department of Medicine, Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil Instituto Dante Pazzanese de Cardiologia, Sao Paulo, SP, Brazil Department of Preventive Medicine, Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil.
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