| Endogenous glucagon-like peptide-1 slows gastric emptying in healthy subjects, attenuating postprandial glycemia. | |
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MedLine Citation:
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PMID: 19892837 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: The role of glucagon-like peptide-1 (GLP-1) in the regulation of gastric emptying is uncertain. The aim of this study was to determine the effects of endogenous GLP-1 on gastric emptying, glucose absorption, and glycemia in health. METHODS: Ten healthy fasted subjects (eight males, two females; 48 +/- 7 yr) received the specific GLP-1 antagonist, exendin(9-39) amide [ex(9-39)NH(2)] (300 pmol/kg x min iv), or placebo, between -30 and 180 min in a randomized, double-blind, crossover fashion. At 0 min, a mashed potato meal ( approximately 2600 kJ) containing 3 g 3-ortho-methyl-D-glucose (3-OMG) and labeled with 20 MBq (99m)Technetium-sulphur colloid was eaten. Gastric emptying, including the time taken for 50% of the meal to empty from the stomach (T50), blood glucose, plasma 3-OMG, and plasma insulin were measured. RESULTS: Ex(9-39)NH(2) accelerated gastric emptying [T50 ex(9-39)NH(2), 68 +/- 8 min, vs. placebo, 83 +/- 7 min; P < 0.001] and increased the overall glycemic response to the meal [area under the curve (0-180 min) ex(9-39)NH(2), 1540 +/- 106 mmol/liter x min, vs. placebo, 1388 +/- 90 mmol/liter x min; P < 0.02]. At 60 min, ex(9-39)NH(2) increased the rise in glycemia [ex(9-39)NH(2), 9.9 +/- 0.5 mmol/liter, vs. placebo, 8.4 +/- 0.5 mmol/liter; P < 0.01], plasma 3-OMG [ex(9-39)NH(2), 0.25 +/- 0.01 mmol/liter, vs. placebo, 0.21 +/- 0.01 mmol/liter; P < 0.05], and plasma insulin [ex(9-39)NH(2), 82 +/- 13 mU/liter, vs. placebo, 59 +/- 9 mU/liter; P < 0.05] concentrations. There was a close within-subject correlation between glycemia and gastric emptying [e.g. at 60 min, the increment in blood glucose and gastric emptying (T50); r = -0.89; P < 0.001]. CONCLUSION: GLP-1 plays a physiological role to slow gastric emptying in health, which impacts on glucose absorption and, hence, postprandial glycemia. |
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Authors:
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Adam M Deane; Nam Q Nguyen; Julie E Stevens; Robert J L Fraser; Richard H Holloway; Laura K Besanko; Carly Burgstad; Karen L Jones; Marianne J Chapman; Chris K Rayner; Michael Horowitz |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2009-11-05 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 95 ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-08 Completed Date: 2010-02-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 215-21 Citation Subset: AIM; IM |
Affiliation:
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Disciplines of Anaesthesia and Intensive Care, University of Adelaide, Adelaide, South Australia 5005 Australia. adam.deane@adelaide.edu.au |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Glucose / analysis, drug effects Cross-Over Studies Double-Blind Method Female Gastric Emptying / drug effects*, physiology Glucagon-Like Peptide 1 / antagonists & inhibitors*, physiology* Guanosine / analogs & derivatives, blood Health Hormone Antagonists / pharmacology Humans Hyperglycemia / prevention & control* Insulin / blood Male Middle Aged Peptide Fragments / pharmacology* Placebos |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Hormone Antagonists; 0/Peptide Fragments; 0/Placebos; 0/exendin (9-39) amide; 10300-27-3/3'-O-methylguanosine; 11061-68-0/Insulin; 118-00-3/Guanosine; 89750-14-1/Glucagon-Like Peptide 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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