Document Detail


Endocytosis and control of Notch signaling.
MedLine Citation:
PMID:  22818956     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Notch signaling pathway controls patterning and cell fate decisions during development in metazoans, and is associated with human diseases such as cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and certain cancers. Studies over the last several years have revealed sophisticated regulation of both the membrane-bound Notch receptor and its ligands by vesicle trafficking. This is perhaps most evident in neural progenitor cells in Drosophila, which divide asymmetrically to segregate Numb, an endocytic adaptor protein that acts as a Notch pathway inhibitor, to one daughter cell. Here, we discuss recent findings addressing how receptor and ligand trafficking to specific membrane compartments control activation of the Notch pathway in asymmetrically dividing cells and other tissues.
Authors:
Vasundhara Kandachar; Fabrice Roegiers
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-07-18
Journal Detail:
Title:  Current opinion in cell biology     Volume:  24     ISSN:  1879-0410     ISO Abbreviation:  Curr. Opin. Cell Biol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-22     Completed Date:  2013-04-05     Revised Date:  2013-08-12    
Medline Journal Info:
Nlm Unique ID:  8913428     Medline TA:  Curr Opin Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  534-40     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Program in Cancer Biology, Fox Chase Cancer Center, Philadelphia, PA 19111, United States.
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MeSH Terms
Descriptor/Qualifier:
Animals
Asymmetric Cell Division
Drosophila Proteins / metabolism
Drosophila melanogaster / cytology,  metabolism
Endocytosis*
Humans
Juvenile Hormones / metabolism
Ligands
Neural Stem Cells / cytology,  metabolism
Protein Transport
Receptors, Notch / metabolism*
Signal Transduction*
Grant Support
ID/Acronym/Agency:
R01 NS059971/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Drosophila Proteins; 0/Juvenile Hormones; 0/Ligands; 0/Receptors, Notch; 0/numb protein, Drosophila
Comments/Corrections

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