| Endocytosis of adenovirus and adenovirus capsid proteins. | |
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MedLine Citation:
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PMID: 14597142 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Key proteins of the icosahedral-shaped adenovirus (Ad) capsid mediate infection, and interact with cellular proteins to coordinate stepwise events of cell entry that produce successful gene transfer. Infection is mediated predominantly by the penton and fiber capsid proteins. The fiber initiates cell binding while the penton binds integrin coreceptors, triggering integrin-mediated endocytosis. Penton integrin signaling precedes viral escape from the endosomal vesicle. After cell binding, the virus undergoes stepwise disassembly of the capsid, shedding proteins during cell entry. Intracellular trafficking of the remaining capsid shell is mediated by the interaction of naked particles with the cytoskeleton. The capsid translocates toward the nucleus, with the majority of capsid proteins accumulating at the nuclear periphery, while viral DNA and associated protein VII are extruded through the nuclear pore. This discussion will encompass the current knowledge on Ad cell entry and trafficking, with an emphasis on the contribution of Ad capsid proteins to these processes. A greater understanding of the highly effective Ad cell entry pathway may lend itself to the development of safer drug and gene delivery alternatives utilizing similar pathways. |
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Authors:
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Lali K Medina-Kauwe |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Advanced drug delivery reviews Volume: 55 ISSN: 0169-409X ISO Abbreviation: Adv. Drug Deliv. Rev. Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-11-04 Completed Date: 2004-07-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8710523 Medline TA: Adv Drug Deliv Rev Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1485-96 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, Institute for Genetic Medicine, 2250 Alcazar Street, CSC240, Los Angeles, CA 90033, USA. medinal@cshs.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenoviridae
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genetics,
metabolism,
physiology* Animals Biological Transport Capsid Proteins / genetics, metabolism, physiology* Cytoskeleton / metabolism Endocytosis / physiology* Endosomes / metabolism Humans Transfection |
| Grant Support | |
ID/Acronym/Agency:
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5 P30 DK048522-09/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Capsid Proteins; 0/penton protein, adenovirus |
| Comments/Corrections | |
Comment In:
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Adv Drug Deliv Rev. 2003 Nov 14;55(11):1353-7
[PMID:
14597135
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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