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Endocrinopathies in Transfusion-Associated Iron Overload.
MedLine Citation:
PMID:  22788934     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Transfusional iron overload primarily results in reticuloendothelial iron accumulation, which is considered to be less harmful than parenchymal iron accumulation. However, systematic and comprehensive data on endocrine function in transfusion-associated hemochromatosis are limited. METHODS: We examined 25 aplastic anemia patients (11 men and 14 women) diagnosed with transfusion-associated hemochromatosis at a single institution. Pituitary function was determined with a combined pituitary function test. On a different day, a 75 g oral glucose tolerance test was performed. The bone mineral density (BMD) of the lumbar spine and total hip was assessed with dual-energy X-ray absorptiometry. RESULTS: Twenty-two (88%) of these 25 patients had at least one endocrine abnormality, and 12 had more than one abnormality. The most common pituitary hormonal deficiency involved the pituitary-gonadal axis; 54% of the total subjects had hypogonadotropic hypogonadism. Two patients had an insufficient cortisol response to corticotropin-releasing hormone stimulation. No patient had a deficiency of growth hormone or thyroid-stimulating hormone. Twelve (48%) had diabetes mellitus and these patients tended to have higher concentrations of ferritin, alanine aminotransferase, and γ-glutamyl transferase. Osteoporosis (T-score < -2.5 SD) was observed in 48% of patients. The reduction in BMD was more pronounced in the lumbar spine than in the total hip. The patients with osteoporosis were accompanied by hypogonadism, which predominantly affected the trabecular bone. CONCLUSIONS: Our observations suggest that endocrinopathies are common in transfusion-associated hemochromatosis. © 2012 Blackwell Publishing Ltd.
Authors:
Mee Kyoung Kim; Jong-Wook Lee; Ki Hyun Baek; Ki-Ho Song; Hyuk-Sang Kwon; Ki-Won Oh; Eun Hee Jang; Moo Il Kang; Kwang Woo Lee
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-12
Journal Detail:
Title:  Clinical endocrinology     Volume:  -     ISSN:  1365-2265     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Affiliation:
Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea.
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