Document Detail


Endocrinology and recurrent early pregnancy loss.
MedLine Citation:
PMID:  22161461     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Endocrine disorders have been frequently linked to recurrent pregnancy loss (RPL). Because embryo attachment and early implantation are exquisitely controlled by the local hormonal milieu, endocrine-related pregnancy failures are likely to occur early in gestation. Thyroid disorders, luteal phase defects, and polycystic ovary syndrome are the endocrine abnormalities most commonly associated with RPL. In this review we discuss new concepts in the pathophysiology and treatment of these diseases with the ultimate goal of improving pregnancy maintenance. We have also included our recommendations on testing and treatment of women with isolated and repeated pregnancy failure that is believed to be at least partially mediated by newly defined hypothyroidism, thyroid autoimmunity, luteal phase defects, obesity, and polycystic ovary syndrome.
Authors:
M Leah Smith; Danny J Schust
Publication Detail:
Type:  Journal Article     Date:  2011-12-08
Journal Detail:
Title:  Seminars in reproductive medicine     Volume:  29     ISSN:  1526-4564     ISO Abbreviation:  Semin. Reprod. Med.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100909394     Medline TA:  Semin Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  482-90     Citation Subset:  IM    
Copyright Information:
© Thieme Medical Publishers.
Affiliation:
Department of Obstetrics, Gynecology and Women's Health, University of Missouri School of Medicine, Columbia, Missouri.
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