Document Detail

Endocrinology of the mammalian fetal testis.
MedLine Citation:
PMID:  20956578     Owner:  NLM     Status:  MEDLINE    
The testes are essential endocrine regulators of fetal masculinization and male development and are, themselves, subject to hormonal regulation during gestation. This review focuses, primarily, on this latter control of testicular function. Data available suggest that, in most mammalian species, the testis goes through a period of independent function before the fetal hypothalamic-pituitary-gonadal axis develops at around 50% of gestation. This pituitary-independent phase coincides with the most critical period of fetal masculinization. Thereafter, the fetal testes appear to become pituitary hormone-dependent, concurrent with declining Leydig cell function, but increasing Sertoli cell numbers. The two orders of mammals most commonly used for these types of studies (rodents and primates) appear to represent special cases within this general hypothesis. In terms of testicular function, rodents are born 'early' before the pituitary-dependent phase of fetal development, while the primate testis is dependent upon placental gonadotropin released during the pituitary-independent phase of development.
Peter J O'Shaughnessy; Paul A Fowler
Related Documents :
21048358 - Successful pregnancy and delivery in a patient with adult gh deficiency: role of gh rep...
3485168 - Corticotrophin-releasing factor-like immunoreactivity and bioactivity of human fetal an...
21928228 - Acute kidney injury in pregnancy: a clinical challenge.
12665708 - Fertility in women with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.
3500078 - Ontogeny of cholinergic innervation of thymus in mouse.
6788618 - Angiotensin-ii sensitivity and prostaglandin-synthetase inhibition in pregnancy.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-18
Journal Detail:
Title:  Reproduction (Cambridge, England)     Volume:  141     ISSN:  1741-7899     ISO Abbreviation:  Reproduction     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-15     Completed Date:  2011-03-25     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  100966036     Medline TA:  Reproduction     Country:  England    
Other Details:
Languages:  eng     Pagination:  37-46     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Animals, Newborn
Fetus / metabolism*
Hormones / metabolism*
Hypothalamo-Hypophyseal System / embryology,  metabolism*
Infant, Newborn
Leydig Cells / metabolism
Pituitary Hormones / metabolism
Placental Hormones / metabolism
Sertoli Cells / metabolism
Signal Transduction*
Spermatozoa / metabolism
Testicular Hormones / metabolism
Testis / embryology,  metabolism*
Grant Support
CZB/4/742//Chief Scientist Office
Reg. No./Substance:
0/Hormones; 0/Pituitary Hormones; 0/Placental Hormones; 0/Testicular Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Sperm quality assessments for endangered razorback suckers Xyrauchen texanus.
Next Document:  Helping Students With Disabilities Better Address Teasing and Bullying Situations: A MASNRN Study.