Document Detail


Endocrinology and immunology of obesity, obesity vaccines.
MedLine Citation:
PMID:  22950959     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The amount of body fat is precisely regulated in the overall process of energy homeostasis. Multiple organ systems participate in the regulatory process. Key regulatory signals reach the brain from the blood and control food intake and energy expenditure. The hypothalamus region integrates neurohormonal signaling from gut and adipose tissue. Morbid obesity is also associated with low grade systemic inflammation and immune activation. It can be at least in part regarded as an inflammatory disease. The anti-ghrelin vaccine decreases food intake, decreases hypothalamic orexigenic signals and increases energy expenditure, therefore might become an alternative treatment tool.
Authors:
Vanja Zjacic Rotkvic
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-03
Journal Detail:
Title:  Current clinical pharmacology     Volume:  -     ISSN:  2212-3938     ISO Abbreviation:  Curr Clin Pharmacol     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101273158     Medline TA:  Curr Clin Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
University of Zagreb, School of Medicine, 'alata 3, Zagreb, Croatia. ziarot@yahoo.com.
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