| Endocrinological, metabolic and clinical features of treatment with oral contraceptive formulation containing ethinylestradiol plus chlormadinone acetate in nonobese women with polycystic ovary syndrome. | |
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MedLine Citation:
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PMID: 20654753 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Chlormadinone acetate (CMA) is a progestin compound similar to progesterone, with antiandrogenic properties. In healthy eumenorrheic women, it was demonstrated that the monophasic estroprogestin formulation containing CMA (2 mg) plus ethinyl estradiol (EE) (30 mcg) (EE30+CMA) is efficacious both in reducing hyperandrogenic symptoms, fat mass and in improving lipoprotein panel, without changes in insulin-glucose metabolism. These metabolic properties are important for women affected by polycystic ovary syndrome (PCOS) in whom there is a predisposition to insulin resistance. STUDY DESIGN: We studied whether in young nonobese women with PCOS (15 subjects, EE30+CMA-PCOS group) a six-cycle treatment with EE30+CMA can reduce androgen levels, androgen bioavailability and the score of hirsutism and acne, and modify glucose-insulin metabolism evaluated by the oral glucose tolerance test and the body composition evaluated by bio-impedenziometry. These parameters were evaluated before (first visit) and during the sixth cycle of EE30+CMA (second visit). All the results were compared with those of a matched-age-group of nonobese PCOS women (15 subjects, no OC-PCOS group) evaluated before (first visit) and after six menstrual cycles in which they did not use any drug or oral contraceptive (second visit). RESULTS: In the EE30+CMA-PCOS group women, androgen levels and bioavailability, hirsutism and acne score were significantly lower at the second than at the first visit, whereas they did not change in no OC-PCOS group. At the second visit, in both groups, glucose-insulin metabolism and body composition parameters were not affected. CONCLUSIONS: A six-cycle treatment with EE30+CMA is efficacious in nonobese PCOS women to improve hyperandrogenic symptoms, without negative interferences both on body composition and on insulin-glucose metabolism. |
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Authors:
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Roberto Uras; Marisa Orrù; Fabiana Pani; Maria Francesca Marotto; Monica Pilloni; Stefano Guerriero; Rossella Etzi; Pierina Zedda; Roberto Sorge; Stefano Lello; Gian Benedetto Melis; Anna Maria Paoletti |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-01 |
Journal Detail:
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Title: Contraception Volume: 82 ISSN: 1879-0518 ISO Abbreviation: Contraception Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-26 Completed Date: 2010-11-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0234361 Medline TA: Contraception Country: United States |
Other Details:
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Languages: eng Pagination: 131-8 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Obstetrics and Gynaecology, University of Cagliari, 09124 Cagliari, Italy. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Acne Vulgaris
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physiopathology Androgens / blood Anthropometry Body Composition / physiology Chlormadinone Acetate / administration & dosage, pharmacology*, therapeutic use Contraceptives, Oral, Combined / administration & dosage, pharmacology*, therapeutic use Electric Impedance Ethinyl Estradiol / administration & dosage, pharmacology*, therapeutic use Female Glucose / analysis, metabolism* Glucose Tolerance Test Hirsutism / physiopathology Humans Insulin / analysis, metabolism* Polycystic Ovary Syndrome / drug therapy*, metabolism Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Androgens; 0/Contraceptives, Oral, Combined; 11061-68-0/Insulin; 302-22-7/Chlormadinone Acetate; 50-99-7/Glucose; 57-63-6/Ethinyl Estradiol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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