Document Detail


Endocrine responses to nocturnal eating--possible implications for night work.
MedLine Citation:
PMID:  12638028     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Night work is becoming more common and shift workers display several metabolic disturbances. Aim To study the endocrine responses in relation to time of day during a 24-h period and how dietary macronutrient composition affects these responses. DESIGN: Seven males (26-43 y and 19.9-26.6 kg. m(-2)) were studied in a crossover design. Isocaloric diets described as high-carbohydrates (HC; 65 energy percent (E%) carbohydrates and 20E% fat) or high-fat (HF; 40E% carbohydrates and 45E% fat) were given. After a 6-day diet adjustment period, the subjects were kept awake for 24 h in a metabolic unit and were served an isocaloric meal (continuation of respective diet) every 4-h. Blood samples were taken throughout the 24-h period. RESULTS: Insulin and leptin responses to meal intake differed with respect to time of day (p < 0.05). Time of day affected glucagon, thyroid stimulating hormone (TSH), free thyroxin (fT4), total triiodothyronine (tT3), cortisol, chromogranin A (CgA) and pancreatic polypeptide (PP) concentrations (p < 0.05). Meal intake decreased cortisol concentration after meals at 0800, 1200 and 0400 but not at 1600, 2000 and 0000 h. The PP's postprandial increase was greater during 0800-1600 h compared to 2000-0800 h. With the HC meals, lower glucagon and CgA concentrations (p < 0.05), and a tendency for lower tT3 concentrations (p = 0.053) were observed compared to the HF meals. CONCLUSION: Insulin, PP, TSH, fT4, cortisol and leptin responses to meal intake differed with respect to time of day. The decreased evening/nocturnal responses of cortisol and PP to meal intake indicate that nocturnal eating and night work might have health implications.
Authors:
Ulf Holmbäck; Anders Forslund; Arne Lowden; Jeanette Forslund; Torbjörn Akerstedt; Maria Lennernäs; Leif Hambraeus; Mats Stridsberg
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of nutrition     Volume:  42     ISSN:  1436-6207     ISO Abbreviation:  Eur J Nutr     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-03-14     Completed Date:  2003-11-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100888704     Medline TA:  Eur J Nutr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  75-83     Citation Subset:  IM    
Affiliation:
Department of Medical Sciences, Clinical Chemistry, Uppsala University Hospital, 751 85 Uppsala, Sweden. ulf.holmback@medsci.uu.se
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MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
Circadian Rhythm / physiology*
Cross-Over Studies
Dietary Carbohydrates / metabolism
Dietary Fats / metabolism
Feeding Behavior / physiology*
Hormones / blood*
Humans
Male
Neurosecretory Systems / physiology*
Time Factors
Work Schedule Tolerance / physiology*
Chemical
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Dietary Fats; 0/Hormones

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