| Endocrine regulation of uncoupling proteins and energy expenditure. | |
| | |
MedLine Citation:
|
PMID: 10997617 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Regulatory thermogenesis occurs upon exposure to the cold or during food intake. Among a variety of mechanisms leading to heat production, uncoupling of respiration in brown adipocyte mitochondria appears to be a major contributor to resistance to the cold in rodents. This uncoupling mechanism is due to the activity of uncoupling protein-1 (UCP-1), a specific carrier present in the inner membrane of mitochondria. The recent identification of UCP-2 and UCP-3, two homologues of the brown fat UCP, suggested that respiration uncoupling could contribute to thermogenesis in most tissues. Activity and expression of the three UCP's are stimulated by several neuromediators and hormones such as noradrenaline, tri-iodothyronine and leptin. |
| | |
Authors:
|
D Ricquier; B Miroux; M Larose; A M Cassard-Doulcier; F Bouillaud |
Related Documents
:
|
18559657 - Brain apolipoprotein e: an important regulator of food intake in rats. 19164587 - Evidence of gender differences in the ability to inhibit brain activation elicited by f... 9205417 - Serum leptin and short-term regulation of eating in obese women. 22834047 - Prêt-à-manger: why the french have their cake and eat it, too. 16400887 - Adverse reactions to food additives. 1019677 - Psychotherapy as adjunct in treatment of vomiting during pregnancy. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity Volume: 24 Suppl 2 ISSN: 0307-0565 ISO Abbreviation: Int. J. Obes. Relat. Metab. Disord. Publication Date: 2000 Jun |
Date Detail:
|
Created Date: 2000-10-10 Completed Date: 2000-10-10 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9313169 Medline TA: Int J Obes Relat Metab Disord Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: S86-8 Citation Subset: IM |
Affiliation:
|
Centre National de la Recherche Scientifique-Unité 9078, Meudon, France. ricquier@infobiogen.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adipose Tissue, Brown
/
physiology Animals Body Temperature Regulation Carrier Proteins / physiology* Endocrine Glands / physiology* Energy Metabolism* Humans Ion Channels Membrane Transport Proteins* Mitochondrial Proteins* Proteins / physiology* Sympathetic Nervous System / physiology Uncoupling Agents* |
| Chemical | |
Reg. No./Substance:
|
0/Carrier Proteins; 0/Ion Channels; 0/Membrane Transport Proteins; 0/Mitochondrial Proteins; 0/Proteins; 0/Uncoupling Agents; 0/mitochondrial uncoupling protein 2; 0/mitochondrial uncoupling protein 3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Neuroendocrine abnormalities in visceral obesity.
Next Document: Adrenomedullary function and its regulation in obesity.