| Endocrine regulation of carbohydrate metabolism in hypometabolic animals. | |
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MedLine Citation:
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PMID: 11537401 Owner: NASA Status: MEDLINE |
Abstract/OtherAbstract:
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Experimental hypothermia and natural hibernation are two forms of hypometabolism with recognized physiological changes, including depression of endocrine and metabolic functions. To better understand functional changes, helox (i.e., helium and oxygen (80:20) mixtures) and low ambient temperatures have been used to induce hypothermia in hamsters and rats. Both clinical and biological survival, i.e., survival without recovery and survival with recovery from hypothermia, respectively, are related to depth and length of hypothermia. In the rat, body temperatures of 15 degrees C for periods greater than 6-10 h greatly restrict biological survival. The role of glucocorticoids in enhancing thermogenic capacity of rats was assessed using triamcinolone [correction of triamcinalone] acetonide. In the hamster, treatment with cortisone acetate prolonged both clinical and biological survival. Hypothermic hamsters continue utilizing circulating glucose until they become hypoglycemic and die. Hypothermic rats do not utilize glucose and respond with a significant hypoinsulinema. The role of endocrines in the regulation of carbohydrate homeostasis and metabolism differs in hibernation and hypothermia. Glucocorticoids influence the hypothermic response in both species, specifically by prolonging induction of hypothermia in rats and by prolonging survival in hypothermic hamsters. |
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Authors:
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X J Musacchia |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Canadian journal of zoology Volume: 66 ISSN: 0008-4301 ISO Abbreviation: Can. J. Zool. Publication Date: 1988 |
Date Detail:
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Created Date: 1995-06-16 Completed Date: 1995-06-16 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0372716 Medline TA: Can J Zool Country: CANADA |
Other Details:
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Languages: eng Pagination: 167-72 Citation Subset: S |
Affiliation:
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Department of Physiology and Biophysics, School of Medicine, University of Louisville, KY 40292. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Medulla
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physiology Animals Body Temperature Carbohydrate Metabolism* Cold Temperature Cortisone / analogs & derivatives, pharmacology, therapeutic use Cricetinae Helium Hibernation / drug effects*, physiology Hypothermia / chemically induced, drug therapy, metabolism* Hypothermia, Induced / adverse effects, methods* Mice Oxygen Rats Sympathetic Nervous System / physiology Time Factors Triamcinolone Acetonide / pharmacology, therapeutic use |
| Chemical | |
Reg. No./Substance:
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50-04-4/cortisone acetate; 53-06-5/Cortisone; 7440-59-7/Helium; 76-25-5/Triamcinolone Acetonide; 7782-44-7/Oxygen |
| Investigator | |
Investigator/Affiliation:
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X J Musacchia / U of Louisville, KY, Med School, Dept Physiol and Biophys |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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