| Endocrine pancreas: summary of observations generated by surgical fellows. | |
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MedLine Citation:
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PMID: 11344400 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present article summarizes scientific observations of the endocrine pancreas anatomy and physiology into a unifying hypothesis. The data were generated over the years by surgical fellows using human and rat isolated perfused pancreas models and in vivo islet microcirculation models. The endocrine pancreas secretes a hormonal milieu regulated by neural, hormonal, and nutritional stimuli and the microcirculation. Variation of the nutrient and hormone concentrations in the islet capillaries generates two levels of response. A first level of response is in the central nervous system (CNS). Cholinergic signals from the CNS regulate the islet microcirculation through internal and external gates. This regulation is mediated by nitric oxide (NO). The gates are endothelial cells found in feeding arterioles and capillaries of the islet capable of directing blood flow through changes in cellular shape. External gates shunt flow to the entire endocrine pancreas, and internal gates divert blood flow within the islet to expose selectively the appropriate cell type required for changes in hormonal milieu. The second level is within the islet. The islet cells respond directly to variations in hormonal and nutrient concentrations. There is extensive communication between the various types of islet cells regulated by NO and hormonal feedback loops. The two levels of response allow an appropriate hormonal milieu, which secreted into the bloodstream contributes to the maintenance of glucose homeostasis. |
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Authors:
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S Moldovan; F C Brunicardi |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review Date: 2001-04-11 |
Journal Detail:
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Title: World journal of surgery Volume: 25 ISSN: 0364-2313 ISO Abbreviation: World J Surg Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-05-09 Completed Date: 2001-08-09 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7704052 Medline TA: World J Surg Country: United States |
Other Details:
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Languages: eng Pagination: 468-73 Citation Subset: IM |
Affiliation:
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Michael E. DeBakey Department of Surgery, Baylor College of Medicine, 6550 Fannin, Suite 1661, Houston, Texas 77030, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Glucagon / physiology Glucose / metabolism Homeostasis Humans Insulin / physiology Islets of Langerhans / anatomy & histology*, blood supply, physiology* Microcirculation Models, Animal Pancreatic Hormones / metabolism Rats Somatostatin / physiology |
| Grant Support | |
ID/Acronym/Agency:
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DK46441-08/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Pancreatic Hormones; 11061-68-0/Insulin; 50-99-7/Glucose; 51110-01-1/Somatostatin; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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