Document Detail

Endocrine induced changes in brain function during pregnancy.
MedLine Citation:
PMID:  20869351     Owner:  NLM     Status:  In-Process    
The female sex steroid hormones, estrogens and progesterone, are produced in large amounts in pregnancy, increasing as pregnancy progresses. These hormones have essential peripheral actions to maintain pregnancy, and to secure safe delivery at term. They also have important actions on the brain in pregnancy, generally through interactions with neuropeptide systems in the brain, or through modulating the actions of circulating peptide hormones on the brain. Together, these steroid-peptide links form short chains that evoke changes in central physiological systems that favour the pregnancy, including altered control of water and electrolyte balance, appetite and energy partitioning and stress responses. In parallel such links prepare the brain, through inhibition of oxytocin secretion until it is needed to support parturition and for immediate expression of maternal behaviour postpartum. We focus here on recent advances in understanding some of these steroid-peptide links, especially on non-classical progesterone actions through allopregnanolone, its neuroactive steroid metabolite, and opioid peptide mechanisms.
Paula J Brunton; John A Russell
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-22
Journal Detail:
Title:  Brain research     Volume:  1364     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  198-215     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Laboratory of Neuroendocrinology, Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK.
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Grant Support
//Biotechnology and Biological Sciences Research Council

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