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Endocrine-immune interactions in pregnant non-human primates with intrauterine infection.
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MedLine Citation:
PMID:  18476167     Owner:  NLM     Status:  In-Data-Review    
Preterm birth remains the most common cause of perinatal mortality. Although the causes of preterm labor are multifactorial and vary according to gestational age, preterm labor and term labor share common cellular and molecular mechanisms, including stimulation of the fetal hypothalamic-pituitary-adrenal (HPA) axis and endocrine/immune system interactions. We have developed a non-human primate experimental model for intrauterine infection and preterm labor using chronically instrumented rhesus monkeys (Macaca mulatta) with timed gestations. We have documented the temporal and quantitative relationships among intrauterine infection, the synthesis and release of proinflammatory cytokines, prostaglandins, and fetal-placental steroid biosynthesis in this model. Infection-induced preterm parturition is characterized by significant elevations in amniotic fluid proinflammatory cytokines and by increases in fetal adrenal steroid biosynthesis, but not by corresponding increases in placental estrogen biosynthesis characteristic of spontaneous parturition. This suggests that activation of the fetal HPA axis by the stress of infection is accompanied by placental dysfunction and also that infection-induced preterm parturition is not dependent upon the increased estrogen biosynthesis observed in spontaneous parturition. These different endocrine and immune responses have important diagnostic and therapeutic implications in the management of preterm labor.
M G Gravett; M J Novy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Infectious diseases in obstetrics and gynecology     Volume:  5     ISSN:  1064-7449     ISO Abbreviation:  Infect Dis Obstet Gynecol     Publication Date:  1997  
Date Detail:
Created Date:  2008-05-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9318481     Medline TA:  Infect Dis Obstet Gynecol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  142-53     Citation Subset:  -    
Division of Reproductive Sciences Oregon Regional Primate Research Center 505 NW 185th Avenue Beaverton OR 97006 USA.
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Journal Information
Journal ID (nlm-ta): Infect Dis Obstet Gynecol
ISSN: 1064-7449
ISSN: 1098-0997
Publisher: Hindawi Publishing Corporation
Article Information
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Copyright ? 1997 Hindawi Publishing Corporation.
open-access: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received Day: 1 Month: 10 Year: 1997
Accepted Day: 21 Month: 10 Year: 1997
Print publication date: Year: 1997
Volume: 5 Issue: 2
First Page: 142 Last Page: 153
ID: 2364569
PubMed Id: 18476167
Publisher Item Identifier: S1064744997000227
DOI: 10.1155/S1064744997000227

Endocrine-Immune Interactions in Pregnant Non-Human Primates With Intrauterine Infection
Michael G. Gravett123
Miles J. Novy13
1Division of Reproductive SciencesOregon Regional Primate Research Center505 NW 185th AvenueBeavertonOR97006USA
2Departments of Obstetrics and GynecologyLegacy Emanuel Hospital and Health CenterPortlaudOregonUSA
3Oregon Health Sciences UniversityBeaverton and PortlandOregonUSA

Article Categories:
  • Research Article

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