Document Detail

Endocrine immune interactions in human parturition.
MedLine Citation:
PMID:  20708653     Owner:  NLM     Status:  MEDLINE    
Human parturition is an inflammatory event, modulated and influenced by a host of other environmental and physiological processes, including the endocrine hormones. Complex bidirectional communication occurs between the two systems to bring about some of the changes that are seen in labour, an event that is not yet fully understood. Preterm birth is a major problem in obstetrics and neonatology, with dysfunctional labour or prolonged pregnancy also making increasingly significant contributions to maternal morbidity. With better understanding of normal and abnormal parturition we may be able to develop novel ways of treating these complications of pregnancy and reduce maternal and neonatal morbidity and mortality. This review discusses the crucial role that endocrine-immune interaction plays in the process of labour and in the processes of abnormal and preterm labour. We propose that amongst these complex interactions it is the immune system that is the driving force behind human parturition.
E Golightly; H N Jabbour; J E Norman
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-08-12
Journal Detail:
Title:  Molecular and cellular endocrinology     Volume:  335     ISSN:  1872-8057     ISO Abbreviation:  Mol. Cell. Endocrinol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-21     Completed Date:  2011-06-13     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  7500844     Medline TA:  Mol Cell Endocrinol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  52-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Cervix Uteri / cytology,  immunology,  metabolism
Cytokines / metabolism
Extraembryonic Membranes / immunology,  metabolism
Hormones / metabolism
Inflammation / immunology*
Myometrium / cytology,  immunology,  metabolism
Parturition / immunology*,  metabolism
Premature Birth / immunology,  prevention & control
Grant Support
G1002033//Medical Research Council; MC_U127684438//Medical Research Council
Reg. No./Substance:
0/Cytokines; 0/Hormones

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