| Endocrine function of granulosa cell tumors in vivo. | |
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MedLine Citation:
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PMID: 1563659 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two patients with granulosa cell tumors of the ovary, endometrial hyperplasia, elevated serum estradiol (E2) concentrations and depressed FSH levels were studied preoperatively using intravenous administration of FSH, LH and gonadotropin-releasing hormone. In patient 1, serum E2 increased from a baseline of 72.7 to 116.8 pg/ml 60 min after hCG stimulation, with a peak level of 571.4 pg/ml 96 h after hCG administration; there was a rapid postoperative decline to 16 pg/ml. Ovarian venous E2 on the tumor side was 6,979 pg/ml. In patient 2, E2 increased from a baseline of 91 to 449 pg/ml at 20 h after FSH administration. Intraoperative ovarian venous E2 was 9,788 pg/ml. Inhibin, which was elevated in patient 1 prior to stimulation (736 fmol/ml), peaked 96 h after hCG administration. Ovarian venous inhibin concentration in patient 1 was 2,911 fmol/ml. The baseline inhibin concentration in patient 2 was not elevated (249 fmol/ml), but there was an elevation of inhibin in response to FSH administration (757 fmol/ml), but no response to hCG. Ovarian inhibin concentration was not different between the tumor and contralateral sides in patient 2. Both granulosa cell tumors were responsive to exogenous gonadotropin stimulation. Although only one tumor made significant baseline levels of inhibin, the production of inhibin by both tumors was apparently stimulated by FSH. |
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Authors:
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B R Witt; G C Wolf; C J Wainwright; I H Thorneycroft |
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Publication Detail:
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Type: Case Reports; Comparative Study; Journal Article |
Journal Detail:
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Title: Gynecologic and obstetric investigation Volume: 33 ISSN: 0378-7346 ISO Abbreviation: Gynecol. Obstet. Invest. Publication Date: 1992 |
Date Detail:
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Created Date: 1992-05-19 Completed Date: 1992-05-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7900587 Medline TA: Gynecol Obstet Invest Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 59-64 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Tulane University School of Medicine, New Orleans, LA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Estradiol / blood, secretion* Female Gonadotropin-Releasing Hormone / administration & dosage, diagnostic use, pharmacology Granulosa Cell Tumor / blood, secretion*, surgery Hormones / administration & dosage, diagnostic use, pharmacology Humans Inhibins / blood, secretion* Injections, Intravenous Intraoperative Period Luteinizing Hormone / administration & dosage, diagnostic use, pharmacology Middle Aged Ovarian Neoplasms / blood, secretion*, surgery Postoperative Period Progesterone / blood, secretion* Stimulation, Chemical |
| Chemical | |
Reg. No./Substance:
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0/Hormones; 33515-09-2/Gonadotropin-Releasing Hormone; 50-28-2/Estradiol; 57-83-0/Progesterone; 57285-09-3/Inhibins; 9002-67-9/Luteinizing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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