Document Detail


Endocrine effects of IGF-I on normal and transformed breast epithelial cells: potential relevance to strategies for breast cancer treatment and prevention.
MedLine Citation:
PMID:  9516077     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Insulin-like growth factors (IGFs) are mitogenic and anti-apoptotic peptides that influence the proliferative behavior of many cell types, including normal and transformed breast epithelial cells. IGF-I has properties of both a tissue growth factor and a systemic hormone: there is evidence that IGF bioactivity in tissues is influenced not only by local factors such as tissue expression of IGFs, IGF binding proteins (IGFBPs), and IGFBP proteases, but also by factors that regulate whole-body IGF physiology and circulating IGF-I levels. Experimental evidence that interventions that reduce circulating IGF-I levels reduce proliferation of breast neoplasms has raised interest in the possibility of developing novel endocrine therapies that target the growth hormone/IGF-I axis. Furthermore, influences of the growth hormone/IGF-I axis on normal breast epithelial cells may underlie recent epidemiological observations that suggest that premenopausal women with high circulating IGF-I level are at increased risk for breast cancer. These studies suggest that the growth hormone/IGF-I axis deserves investigation as a possible target for novel breast cancer prevention strategies.
Authors:
M N Pollak
Related Documents :
22053997 - Common breast cancer susceptibility alleles are associated with tumour subtypes in brca...
18826367 - Hypophysectomy for prostate cancer: a revival of old knowledge?
16942817 - Multiple bronchioloalveolar carcinomas in acromegaly: a potential role of insulin-like ...
24664617 - Determinants of optimal mastectomy skin flap thickness.
12456287 - Absence of evidence for differences in the dose-response for cancer and non-cancer endp...
24804617 - Contralateral breast volume measurement during chest ct for postmastectomy breast recon...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Breast cancer research and treatment     Volume:  47     ISSN:  0167-6806     ISO Abbreviation:  Breast Cancer Res. Treat.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-05-04     Completed Date:  1998-05-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8111104     Medline TA:  Breast Cancer Res Treat     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  209-17     Citation Subset:  IM    
Affiliation:
Department of Medicine, Lady Davis Research Institute of the Jewish General Hospital and McGill University, Montreal, Quebec, Canada. MD49@MUSICA.MCGILL.CA
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Breast Neoplasms / pathology*,  prevention & control,  therapy*
Epithelial Cells / pathology
Female
Humans
Insulin-Like Growth Factor I / metabolism,  pharmacology,  physiology*
Mammary Neoplasms, Experimental / pathology,  prevention & control,  therapy
Chemical
Reg. No./Substance:
67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Role of IGF-I in normal mammary development.
Next Document:  Paracrine/autocrine regulation of breast cancer by the insulin-like growth factors.