Document Detail

Endocrine effects of IGF-I on normal and transformed breast epithelial cells: potential relevance to strategies for breast cancer treatment and prevention.
MedLine Citation:
PMID:  9516077     Owner:  NLM     Status:  MEDLINE    
Insulin-like growth factors (IGFs) are mitogenic and anti-apoptotic peptides that influence the proliferative behavior of many cell types, including normal and transformed breast epithelial cells. IGF-I has properties of both a tissue growth factor and a systemic hormone: there is evidence that IGF bioactivity in tissues is influenced not only by local factors such as tissue expression of IGFs, IGF binding proteins (IGFBPs), and IGFBP proteases, but also by factors that regulate whole-body IGF physiology and circulating IGF-I levels. Experimental evidence that interventions that reduce circulating IGF-I levels reduce proliferation of breast neoplasms has raised interest in the possibility of developing novel endocrine therapies that target the growth hormone/IGF-I axis. Furthermore, influences of the growth hormone/IGF-I axis on normal breast epithelial cells may underlie recent epidemiological observations that suggest that premenopausal women with high circulating IGF-I level are at increased risk for breast cancer. These studies suggest that the growth hormone/IGF-I axis deserves investigation as a possible target for novel breast cancer prevention strategies.
M N Pollak
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Breast cancer research and treatment     Volume:  47     ISSN:  0167-6806     ISO Abbreviation:  Breast Cancer Res. Treat.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-05-04     Completed Date:  1998-05-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8111104     Medline TA:  Breast Cancer Res Treat     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  209-17     Citation Subset:  IM    
Department of Medicine, Lady Davis Research Institute of the Jewish General Hospital and McGill University, Montreal, Quebec, Canada. MD49@MUSICA.MCGILL.CA
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MeSH Terms
Breast Neoplasms / pathology*,  prevention & control,  therapy*
Epithelial Cells / pathology
Insulin-Like Growth Factor I / metabolism,  pharmacology,  physiology*
Mammary Neoplasms, Experimental / pathology,  prevention & control,  therapy
Reg. No./Substance:
67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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