Document Detail


Endocrine disrupting chemicals and disease susceptibility.
MedLine Citation:
PMID:  21899826     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Environmental chemicals have significant impacts on biological systems. Chemical exposures during early stages of development can disrupt normal patterns of development and thus dramatically alter disease susceptibility later in life. Endocrine disrupting chemicals (EDCs) interfere with the body's endocrine system and produce adverse developmental, reproductive, neurological, cardiovascular, metabolic and immune effects in humans. A wide range of substances, both natural and man-made, are thought to cause endocrine disruption, including pharmaceuticals, dioxin and dioxin-like compounds, polychlorinated biphenyls, DDT and other pesticides, and components of plastics such as bisphenol A (BPA) and phthalates. EDCs are found in many everyday products--including plastic bottles, metal food cans, detergents, flame retardants, food additives, toys, cosmetics, and pesticides. EDCs interfere with the synthesis, secretion, transport, activity, or elimination of natural hormones. This interference can block or mimic hormone action, causing a wide range of effects. This review focuses on the mechanisms and modes of action by which EDCs alter hormone signaling. It also includes brief overviews of select disease endpoints associated with endocrine disruption.
Authors:
Thaddeus T Schug; Amanda Janesick; Bruce Blumberg; Jerrold J Heindel
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-08-27
Journal Detail:
Title:  The Journal of steroid biochemistry and molecular biology     Volume:  127     ISSN:  1879-1220     ISO Abbreviation:  J. Steroid Biochem. Mol. Biol.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-18     Completed Date:  2012-01-12     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  9015483     Medline TA:  J Steroid Biochem Mol Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  204-15     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Ltd.
Affiliation:
National Institute of Environmental Health Sciences, Division of Extramural Research and Training, Cellular, Organ and Systems Pathobiology Branch, Research Triangle Park, NC 27709, USA. schugt@niehs.nih.gov
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Susceptibility*
Dose-Response Relationship, Drug
Endocrine Disruptors / toxicity*
Environmental Pollutants / toxicity*
Female
Humans
Male
Metabolic Diseases / chemically induced
Obesity / chemically induced
Pregnancy
Reproduction / drug effects
Grant Support
ID/Acronym/Agency:
Z99 ES999999/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Endocrine Disruptors; 0/Environmental Pollutants
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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