Document Detail

Endocrine control of steroidogenesis in granulosa cells.
MedLine Citation:
PMID:  1331938     Owner:  NLM     Status:  MEDLINE    
This review offers a summary of an increasingly complex literature which exists on the specific endocrine control of granulosa cell steroidogenesis. Further developments in cell biology will ultimately aid our greater understanding of pathophysiological regulation of the ovarian events underlying the human menstrual cycle. While we are beginning to unravel many of the important operational facets of this integrated process, our knowledge is still limited. Important questions remain to many clinical syndromes involving altered ovarian function, for example primary ovarian failure, polycystic ovary disease, resistant ovary syndrome, and so on. However, with the rapid continuing expansion of cellular and molecular technologies gaps in our understanding may be bridged in the near future, and thus enable physicians to evaluate better and treat disorders of ovarian function.
R J Urban; J D Veldhuis
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Oxford reviews of reproductive biology     Volume:  14     ISSN:  0260-0854     ISO Abbreviation:  Oxf Rev Reprod Biol     Publication Date:  1992  
Date Detail:
Created Date:  1992-12-02     Completed Date:  1992-12-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8005460     Medline TA:  Oxf Rev Reprod Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  225-62     Citation Subset:  IM    
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MeSH Terms
Adrenocorticotropic Hormone / physiology
Catecholamines / physiology
Cytokines / physiology
Endocrine Glands / physiology*
Enzyme Precursors / physiology
Gonadal Steroid Hormones / physiology
Gonadotropin-Releasing Hormone / physiology
Granulosa Cells / metabolism*
Growth Substances / physiology
Hypothalamic Hormones / physiology
Inhibins / physiology
Pituitary Hormones / physiology
Renin / physiology
Steroids / biosynthesis*
Grant Support
Reg. No./Substance:
0/Catecholamines; 0/Cytokines; 0/Enzyme Precursors; 0/Gonadal Steroid Hormones; 0/Growth Substances; 0/Hypothalamic Hormones; 0/Pituitary Hormones; 0/Steroids; 33515-09-2/Gonadotropin-Releasing Hormone; 57285-09-3/Inhibins; 9002-60-2/Adrenocorticotropic Hormone; EC

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