Document Detail


Endocrine and clinical effects of myo-inositol administration in policystyc ovary syndrome. A randomized study.
MedLine Citation:
PMID:  23336594     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective: To evaluate the effects the administration of myo-inositol (MYO) on hormonal parameters in a group of polycystic ovary syndrome (PCOS) patients. Design: Controlled clinical study. Setting: PCOS patients in a clinical research environment. Patients: 50 overweight PCOS patients were enrolled after informed consent. Interventions: All patients underwent hormonal evaluations and an oral glucose tolerance test (OGTT) before and after 12 weeks of therapy (Group A (n¼10): MYO 2 g plus folic acid 200 mg every day; Group B (n¼10): folic acid 200 mg every day). Ultrasound examinations and Ferriman-Gallwey score were also performed. Main outcome measures: Plasma LH, FSH, PRL, E2, 17OHP, A, T, glucose, insulin, C peptide concentrations, BMI, HOMA index and glucose-to-insulin ratio. Results: After 12 weeks of MYO administration plasma LH, PRL, T, insulin levels and LH/FSH resulted significantly reduced. Insulin sensitivity, expressed as glucose-to-insulin ratio and HOMA index resulted significantly improved after 12 weeks of treatment. Menstrual cyclicity was restored in all amenorrheic and oligomenorrheic subjects. No changes occurred in the patients treated with folic acid. Conclusions: MYO administration improves reproductive axis functioning in PCOS patients reducing the hyperinsulinemic state that affects LH secretion.
Authors:
P G Artini; O M Di Berardino; F Papini; A D Genazzani; G Simi; M Ruggiero; V Cela
Related Documents :
24477354 - Real-world cost-effectiveness: lower cost of treating patients to glycemic goal with li...
15866064 - Thiazolidinediones-benefits on microvascular complications of type 2 diabetes.
6375614 - Gastrointestinal tract complications of diabetes mellitus. pathophysiology and management.
20644204 - Risks and benefits of attaining hba(1c) goals: examining the evidence.
21273494 - Clinical significance of urinary liver-type fatty acid-binding protein in diabetic neph...
172204 - Pathways of carbohydrate metabolism in mycobacterium tuberculosis h37rv1.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-22
Journal Detail:
Title:  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology     Volume:  -     ISSN:  1473-0766     ISO Abbreviation:  Gynecol. Endocrinol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807913     Medline TA:  Gynecol Endocrinol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology , University of Pisa , Pisa , Italy , and.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Health impacts of the July 2010 heat wave in Québec, Canada.
Next Document:  Quantitative proteomics-based analysis supports a significant role of GTG proteins in regulation of ...