Document Detail

Endocrine changes in women conceiving during treatment with an LHRH agonist.
MedLine Citation:
PMID:  2113928     Owner:  NLM     Status:  MEDLINE    
We report on eight patients who conceived during pituitary desensitization with buserelin in the luteal phase of the menstrual cycle. Pregnancy was diagnosed between day 12 and 21 of buserelin administration. Analysis of serum luteinizing hormone on day 12 showed that pituitary desensitization occurred in conjunction with increasing production of ovarian steroid hormones. Serum concentrations of human chorionic gonadotrophin (HCG) were less than 10 IU/l on day 1 of buserelin administration for seven of the eight patients. The serum concentration of HCG on day 12 showed a median value of 722 IU/l (range 14.6-798 IU/l). Five of the eight patients were given HCG support (10,000 IU) following the diagnosis of pregnancy--three of these patients have ongoing pregnancies and the remaining two had blighted ova on scan. Of the remaining three patients, one had a singleton pregnancy which miscarried at 9 weeks, one had a blighted ovum on scan and bled per vagina shortly after this, and one bled per vagina prior to a scan being carried out. Our results show that pregnancy can occur during pituitary desensitization with buserelin, despite patients being counselled not to have unprotected intercourse in the cycle during which administration commences. An HCG assay on day 1 of buserelin administration is not helpful. Pregnancy should be suspected when ovarian steroid production persists despite complete pituitary down-regulation.
P J Isherwood; Z H Ibrahim; P L Matson; D R Morroll; R W Burslem; B A Lieberman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  5     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-08-08     Completed Date:  1990-08-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  409-12     Citation Subset:  IM    
Manchester Fertility Services, UK.
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MeSH Terms
Buserelin / pharmacology*
Chorionic Gonadotropin / blood*
Estradiol / blood
Luteal Phase
Luteinizing Hormone / blood
Pituitary Gland / drug effects*
Pregnancy / blood,  physiology*
Progesterone / blood
Retrospective Studies
Reg. No./Substance:
0/Chorionic Gonadotropin; 50-28-2/Estradiol; 57-83-0/Progesterone; 57982-77-1/Buserelin; 9002-67-9/Luteinizing Hormone

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