Document Detail

Endocrine changes during 48 hours of food withdrawal in the pregnant rhesus monkey in the last third of gestation.
MedLine Citation:
PMID:  2524502     Owner:  NLM     Status:  MEDLINE    
We studied the hormonal responses in four pregnant rhesus monkeys between 112 and 149 days gestation. After 2 days, during which the monkeys were fed ad libitum, their food was withdrawn at 1500 h for 48 h while allowing free access to water. The food then was returned, and the animals were studied for a further 2 days. The mean maternal whole blood glucose concentration significantly decreased, and plasma cortisol and dehydroepiandrosterone sulfate (DHEAS) concentrations significantly increased within 30 h of food withdrawal (P less than 0.05). The maternal plasma estradiol concentration increased significantly at 1000 h on the second day of food withdrawal (P less than 0.05), whereas the plasma progesterone concentration did not change. The maternal blood glucose and plasma cortisol, DHEAS and estradiol concentrations returned to baseline by the second day of food replacement. We conclude that the stress of hypoglycemia and/or the attendant inability to eat, together or separately, stimulate maternal adrenal glucocorticoid and androgen secretion during the period of food withdrawal. The increased maternal DHEAS and perhaps other adrenal androgen concentrations result in increased maternal estrogen production.
Z Binienda; A Massmann; J Wimsatt; M B Honnebier; J P Figueroa; T J Reimers; P W Nathanielsz
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  68     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-06-30     Completed Date:  1989-06-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1184-8     Citation Subset:  AIM; IM    
Laboratory for Pregnancy and Newborn Research, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853.
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MeSH Terms
Adrenal Glands / physiology*
Androgens / blood
Blood Glucose / analysis
Dehydroepiandrosterone / analogs & derivatives,  blood
Dehydroepiandrosterone Sulfate
Estradiol / blood
Food Deprivation*
Hydrocortisone / blood
Macaca mulatta
Pregnancy, Animal / metabolism*
Progesterone / blood
Grant Support
Reg. No./Substance:
0/Androgens; 0/Blood Glucose; 50-23-7/Hydrocortisone; 50-28-2/Estradiol; 53-43-0/Dehydroepiandrosterone; 57-83-0/Progesterone; 651-48-9/Dehydroepiandrosterone Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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