Document Detail

Endocrine changes and clinical profiles in depression: II. The thyrotropin-releasing hormone test.
MedLine Citation:
PMID:  6443618     Owner:  NLM     Status:  MEDLINE    
Thirty-one (43%) of 68 patients with primary depression were found to have a blunted thyroid-stimulating hormone (TSH) response to thyrotropin-releasing hormone (TRH). Increased thyroid activity, as measured by the free thyroxine index (FTI), was present in 16 (24%) of the patients. Patients with blunted responses had a higher mean FTI level than those with normal responses. Patients with blunted responses were significantly more likely to exhibit the symptoms of depersonalization, derealization and agitation. There was no clear association between blunting and any particular diagnostic category of depression. Patients with blunted responses and high FTI values were more likely to report significant long-term environmental difficulties than patients with blunted responses and normal FTI values. It is suggested that there may be more than one mechanism responsible for blunting of the TSH response in depressed patients. In some patients blunting may be due to negative feedback from increased output of thyroid hormones, possibly released as part of a stress response. In other patients blunting may be due to a different mechanism, possibly involving pituitary gland dysfunction. These mechanisms would not necessarily be mutually exclusive in any one patient.
S P Calloway; R J Dolan; P Fonagy; V F De Souza; A Wakeling
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Psychological medicine     Volume:  14     ISSN:  0033-2917     ISO Abbreviation:  Psychol Med     Publication Date:  1984 Nov 
Date Detail:
Created Date:  1986-02-10     Completed Date:  1986-02-10     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  1254142     Medline TA:  Psychol Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  759-65     Citation Subset:  IM    
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MeSH Terms
Depressive Disorder / diagnosis*,  psychology
Psychological Tests
Thyrotropin / blood*
Thyrotropin-Releasing Hormone / diagnostic use*
Thyroxine / blood
Triiodothyronine / blood
Reg. No./Substance:
24305-27-9/Thyrotropin-Releasing Hormone; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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