Document Detail

Endocrine cells in the human common bile duct in patients with obstructive jaundice.
MedLine Citation:
PMID:  22251519     Owner:  NLM     Status:  In-Data-Review    
Background/Aims: There was no data about endocrine cells in the extrahepatic bile duct in secondary cholangitis due to obstructive jaundice. The aim of the present study is to investigate immunohistochemically the endocrine cell types in the lower part of the human common bile duct in biopsy samples, collected during drainage because of complete or incomplete obstruction, caused mainly by stones. We explained the presence of various hormone-producing endocrine cells in this region with the regulation of physiological and pathological processes there. Methodology: We used light and electron microscopic immunohistochemistry. Results: More Gastrin-positive, Somatostatin-positive, Secretin-positive, Serotonin-positive, Chromogranin- A-positive and Synaptophysin-positive endocrine cells were found compared to control preparations. Conclusions: Occurrence of endocrine cells may relate to disturbed bile flow and to formation of calculi. Endocrine cell hyperplasia may be related to longstanding inflammation as in chronic cholecystitis and all secreted hormones from the described ECs can support pathologic process in the choledochus, i.e. inflammation, increased mucus secretion, fibrosis, muscle contraction, etc. We may state that various ECs (similar to those in duodenum) present in the lower part of the large bile duct and their hormones exert action on physiology (motility, secretion) and pathology (inflammation and fibrosis) in that part of the biliary tree.
Maya V Gulubov; Philip Hadjipetkov; Dimiter Sivrev; Galya Ilieva
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  59     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:    2012 Jan-Feb
Date Detail:
Created Date:  2012-01-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  26-30     Citation Subset:  IM    
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