Document Detail

Endocrine analytes in multiple-marker screening.
MedLine Citation:
PMID:  9891624     Owner:  NLM     Status:  MEDLINE    
Prenatal serum screening is based on the observation that secretory products of the placenta and fetus are altered in maternal serum of pregnancies affected with certain birth defects. Most of these products are hormones that have been previously characterized, although the pathophysiologic basis of the altered maternal serum levels of these products that occurs in association with fetal chromosome for the most part is unknown. Prenatal serum screening is in a period of transition, with the relatively recent advance of second trimester triple-marker screening (AFP, uE3, hCG) and now the improved performance of the four-marker test that adds inhibin. A. Proposed first trimester screening and other new second trimester serum markers may dramatically change prenatal screening practices as we enter the next century.
G M Lambert-Messerlian; J A Canick
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinics in perinatology     Volume:  25     ISSN:  0095-5108     ISO Abbreviation:  Clin Perinatol     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-01-29     Completed Date:  1999-01-29     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7501306     Medline TA:  Clin Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  963-81, vii     Citation Subset:  IM    
Department of Pathology, Brown University School of Medicine, USA.
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MeSH Terms
Biological Markers / blood
Chorionic Gonadotropin / metabolism*
Estriol / blood*
Inhibins / blood*
Mass Screening / methods*
Maternal Age
Pregnancy Complications / diagnosis*,  metabolism*
Pregnancy Trimester, Second
Prenatal Care / methods*
Reproducibility of Results
alpha-Fetoproteins / metabolism*
Reg. No./Substance:
0/Biological Markers; 0/Chorionic Gonadotropin; 0/alpha-Fetoproteins; 50-27-1/Estriol; 57285-09-3/Inhibins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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