Document Detail


Endocrine effects of GnRH agonist application to early pregnant gilts.
MedLine Citation:
PMID:  21157124     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hypothesis of the present study was that a GnRH agonist application at early pregnancy would alter the pattern of the key reproductive hormones LH and FSH, and subsequently that of estradiol (E2) and especially progesterone (P4), and improve the conditions for embryo survival in early pregnant gilts. Therefore, the endocrine effects of a GnRH agonist (GnRHa) application to gilts (n=11 GnRHa treated, n=9 saline Controls) were studied in blood samples from the Vena cava caudalis. GnRHa injected on Day 12 after insemination induced elevated (P<0.01) LH and FSH levels for at least 180 min. However, subsequent LH concentrations were not altered up to Day 21 of pregnancy. LH pulse number, estimated in 6-h period samples on Days 13, 15 and 17, was not influenced by treatment and pregnancy. LH pulse amplitude was decreased (P<0.05) on Days 13 to 17 in pregnant gilts of both groups, but not in nonpregnant animals. In pregnant GnRHa-treated gilts, the basal LH level was elevated compared with the Controls (P<0.01). Additionally, differences (P<0.05) in basal LH were present between the pregnant and nonpregnant animals. The P4 and E2 secretion pattern was not affected by GnRHa. P4 concentrations increased (P<0.01) from Day 10 to Day 14 regardless of the treatment. P4 revealed a pulse-like pattern, but without a definite relation to the LH pulse characteristics. Also, pregnancy rate (73 vs. 67%) and the number of fetuses (12.8 ± 2.3 vs. 11.6 ± 2.3) were unaffected in the treated and Control gilts, respectively. The present study did not confirm the initial hypothesis that a GnRHa-mediated LH effect could alter ovarian steroid secretion and favorably support early embryo development and pregnancy outcome.
Authors:
Klaus-Peter Brüssow; Falk Schneider; Karin Wollenhaupt; Armin Tuchscherer
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Publication Detail:
Type:  Journal Article     Date:  2010-12-09
Journal Detail:
Title:  The Journal of reproduction and development     Volume:  57     ISSN:  1348-4400     ISO Abbreviation:  J. Reprod. Dev.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-05-09     Completed Date:  2011-09-16     Revised Date:  2011-12-13    
Medline Journal Info:
Nlm Unique ID:  9438792     Medline TA:  J Reprod Dev     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  242-8     Citation Subset:  IM    
Affiliation:
Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany. bruessow@fbn-dummerstorf.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Embryonic Development / drug effects*
Estradiol / blood
Female
Follicle Stimulating Hormone / blood
Gonadotropin-Releasing Hormone / administration & dosage,  agonists*,  analogs & derivatives*
Luteinizing Hormone / blood
Pregnancy
Pregnancy Outcome / veterinary*
Progesterone / blood*
Swine
Chemical
Reg. No./Substance:
33515-09-2/Gonadotropin-Releasing Hormone; 50-28-2/Estradiol; 57-83-0/Progesterone; 57521-78-5/LHRH, Phe(6)-; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone

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