Document Detail


Endocranial vascular patterns in a familial rabbit model of coronal suture synostosis.
MedLine Citation:
PMID:  11681995     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The present study investigates the potential relationship between craniosynostosis and any changes in endocranial vasculature. The hypothesis that crania from rabbits with familial, nonsyndromic coronal suture synostosis and crania from rabbits with experimental immobilization of the coronal suture are associated with altered form of the middle meningeal vessels and dural venous sinuses is tested. DESIGN: Silicone rubber endocasts from 14 adult New Zealand white rabbits (Oryctolagus cuniculus) with familial nonsyndromic coronal suture synostosis (five with bilateral coronal suture synostosis and nine with unilateral coronal suture synostosis) were made to assess middle meningeal vessel and dural venous sinus form. For comparative purposes, endocasts were made from 25 rabbits with normal, patent coronal sutures and 10 rabbits with experimental immobilization of the coronal suture. Impressions of the dural venous sinuses were assessed for depth and width. The area of the confluens of sinuses was also assessed. Impressions of the middle meningeal vessels were assessed for depth, width, and degree of convolution. For width of the dural venous sinuses and area of the confluens of sinuses, comparisons among groups were made with a one-way analysis of variance (ANOVA). For depth of the dural venous sinuses and impressions of the middle meningeal vessels, comparisons among groups were made using a Kruskal-Wallis one-way ANOVA. RESULTS: Crania with familial coronal suture synostosis had significantly (p <.05) reduced posterior dural venous sinus dimensions when compared with both crania from rabbits with experimental immobilization of the coronal suture and rabbits with normal coronal sutures. Crania with both coronal suture synostosis and experimental immobilization had significant increases in dimensions of the middle meningeal vessels relative to normal crania. In addition, casts from rabbits with unicoronal suture synostosis showed marked asymmetry in the dural venous sinuses. CONCLUSIONS: These results support the hypothesis that craniosynostosis is associated with alterations in endocranial vasculature. These changes are most likely a secondary response to synostosis rather than a causal factor and may reflect increased intracranial pressure, decreased intracranial volume, and local accumulations and reductions of cerebrospinal fluid in the posterior region of the skull and immediately deep to the coronal suture.
Authors:
A M Burrows; V D O'Loughlin; M P Mooney; T D Smith; H W Losken; M I Siegel
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association     Volume:  38     ISSN:  1055-6656     ISO Abbreviation:  Cleft Palate Craniofac. J.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-10-29     Completed Date:  2002-01-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9102566     Medline TA:  Cleft Palate Craniofac J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  615-21     Citation Subset:  D; IM    
Affiliation:
School of Physical Therapy, Slippery Rock University, Suite 100 North Road, Slippery Rock, PA 16057, USA. amb11+@pitt.edu
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Cranial Sinuses / pathology
Cranial Sutures / abnormalities,  blood supply*
Craniosynostoses / cerebrospinal fluid,  genetics,  pathology*
Disease Models, Animal
Dura Mater / blood supply
Female
Frontal Bone / abnormalities,  blood supply*
Immobilization
Intracranial Pressure
Male
Meningeal Arteries / pathology
Models, Anatomic
Parietal Bone / abnormalities,  blood supply*
Rabbits
Silicone Elastomers
Statistics, Nonparametric
Grant Support
ID/Acronym/Agency:
DE 10830/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/Silicone Elastomers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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